1) Urea + choline chloride osmotic pressure at 2:1 (Reline) mole ratio and 25 degrees Celsius
We define Reline as two urea and one choline chloride molecules. When mixed together at this 2:1 (urea:cholinechloride mole ratio) ratio, they form a deep eutectic solvent, termed Reline. A 1mol/kg Reline solution contains 2 mol/kg urea and 1mol/kg choline chloride.
References
Please use the following reference when using this data.
Shumilin, Ilan, Ahmad Tanbuz, and Daniel Harries. "Deep Eutectic Solvents for Efficient Drug Solvation: Optimizing Composition and Ratio for Solubility of β-Cyclodextrin." Pharmaceutics 15, no. 5 (2023): 1462. https://10.3390/pharmaceutics15051462.
| Shumilin et al | |
| molality, mol/kg | Osmolality, Osmolal |
| 0.203 | 0.544 |
| 0.422 | 1.287 |
| 0.428 | 1.374 |
| 0.428 | 1.334 |
| 0.953 | 3.059 |
| 0.960 | 2.952 |
| 0.962 | 2.927 |
| 1.647 | 5.040 |
| 1.649 | 5.247 |
| 1.650 | 5.182 |
| 2.555 | 8.171 |
| 2.559 | 7.980 |
| 2.568 | 8.086 |
| 3.821 | 12.324 |
| 3.847 | 12.603 |
| 3.873 | 12.682 |
| 5.757 | 19.158 |
| 5.781 | 19.388 |
| 5.783 | 19.485 |
| 8.787 | 29.954 |
| 9.011 | 30.589 |
| 9.012 | 30.488 |
| 11.572 | 38.143 |
| 15.304 | 49.673 |
| 15.332 | 49.499 |
| 15.368 | 47.205 |
| 16.377 | 50.126 |
| 17.499 | 53.130 |
| 18.751 | 56.666 |
| 20.160 | 59.050 |
| 21.757 | 62.801 |
| 23.579 | 66.106 |
| 25.683 | 70.069 |
| 28.135 | 74.475 |
| 31.032 | 77.851 |
| 34.506 | 81.680 |
| 34.624 | 86.986 |
| 34.651 | 87.101 |
| 38.747 | 88.430 |
| 44.047 | 94.288 |
| 50.848 | 102.674 |
| 59.902 | 110.068 |
| 72.544 | 117.885 |
The data set is adequately captured by the following cubic term:
Osmolal = 0.00023*m^3 - 0.04598*m^2 + 3.75984*m
2) Urea + choline chloride osmotic pressure at all ratios
References
Please use the following reference when using this data:
Shumilin, Ilan, Ahmad Tanbuz, and Daniel Harries. "Deep Eutectic Solvents for Efficient Drug Solvation: Optimizing Composition and Ratio for Solubility of β-Cyclodextrin." Pharmaceutics 15, no. 5 (2023): 1462. https://10.3390/pharmaceutics15051462.
| Shumilin et al. | ||
| [urea], mol/kg | [choline chloride], mol/kg | Osmolality, Osmolal |
| 0.257 | 15.928 | 41.008 |
| 0.406 | 0.203 | 0.558 |
| 0.844 | 0.422 | 1.293 |
| 0.855 | 0.428 | 1.350 |
| 0.998 | 4.999 | 10.687 |
| 1.000 | 2.000 | 4.271 |
| 1.009 | 10.450 | 25.581 |
| 1.700 | 15.757 | 41.241 |
| 1.906 | 0.953 | 3.084 |
| 1.920 | 0.960 | 2.967 |
| 1.925 | 0.962 | 2.908 |
| 1.999 | 9.925 | 24.881 |
| 2.301 | 15.684 | 41.241 |
| 2.788 | 15.626 | 41.241 |
| 2.998 | 4.999 | 12.120 |
| 3.022 | 10.450 | 27.007 |
| 3.295 | 1.647 | 5.057 |
| 3.297 | 1.649 | 5.239 |
| 3.300 | 1.650 | 5.178 |
| 3.972 | 15.486 | 41.124 |
| 4.002 | 2.000 | 6.537 |
| 4.875 | 10.450 | 28.010 |
| 4.987 | 4.999 | 13.448 |
| 5.005 | 19.787 | 54.343 |
| 5.012 | 9.925 | 26.558 |
| 5.109 | 2.555 | 8.186 |
| 5.118 | 2.559 | 7.993 |
| 5.136 | 2.568 | 8.057 |
| 5.466 | 18.138 | 47.668 |
| 5.652 | 18.705 | 48.194 |
| 6.844 | 24.235 | 67.259 |
| 6.980 | 4.999 | 14.737 |
| 6.984 | 15.125 | 41.241 |
| 7.022 | 2.000 | 8.768 |
| 7.346 | 25.854 | 67.633 |
| 7.643 | 3.821 | 12.327 |
| 7.694 | 3.847 | 12.606 |
| 7.747 | 3.873 | 12.675 |
| 7.837 | 9.925 | 28.010 |
| 7.963 | 10.450 | 29.502 |
| 9.025 | 1.999 | 10.151 |
| 9.924 | 10.450 | 30.647 |
| 9.935 | 4.999 | 16.728 |
| 10.142 | 19.978 | 53.318 |
| 10.987 | 14.648 | 41.828 |
| 11.000 | 2.000 | 11.570 |
| 11.018 | 9.925 | 29.691 |
| 11.514 | 5.757 | 19.184 |
| 11.561 | 5.781 | 19.420 |
| 11.566 | 5.783 | 19.499 |
| 11.823 | 21.670 | 57.223 |
| 11.953 | 19.787 | 55.840 |
| 12.623 | 10.450 | 31.915 |
| 12.989 | 1.999 | 13.096 |
| 13.003 | 5.000 | 18.637 |
| 13.508 | 28.061 | 71.721 |
| 13.987 | 9.925 | 31.131 |
| 14.792 | 2.000 | 14.304 |
| 14.901 | 5.000 | 19.815 |
| 14.949 | 10.450 | 33.112 |
| 15.426 | 14.118 | 42.183 |
| 15.468 | 28.332 | 75.052 |
| 16.934 | 1.233 | 15.028 |
| 16.970 | 9.925 | 32.511 |
| 17.398 | 4.999 | 21.426 |
| 17.573 | 8.787 | 29.976 |
| 17.884 | 2.486 | 17.332 |
| 18.021 | 9.011 | 30.551 |
| 18.024 | 1.999 | 16.653 |
| 18.025 | 9.012 | 30.455 |
| 18.064 | 10.450 | 34.439 |
| 18.348 | 2.000 | 16.878 |
| 18.400 | 19.786 | 57.379 |
| 18.534 | 1.662 | 16.578 |
| 18.699 | 5.000 | 22.249 |
| 18.851 | 3.762 | 19.974 |
| 19.199 | 1.791 | 17.105 |
| 19.257 | 4.300 | 21.263 |
| 19.299 | 13.655 | 42.540 |
| 19.724 | 1.898 | 17.408 |
| 19.935 | 9.925 | 33.925 |
| 20.150 | 10.450 | 35.376 |
| 20.217 | 23.941 | 62.612 |
| 20.630 | 6.113 | 25.581 |
| 20.679 | 25.927 | 66.518 |
| 20.765 | 3.094 | 20.214 |
| 21.000 | 13.453 | 42.779 |
| 21.441 | 3.045 | 20.534 |
| 21.607 | 7.401 | 28.844 |
| 21.844 | 9.925 | 34.853 |
| 21.908 | 1.920 | 18.949 |
| 21.976 | 13.336 | 42.659 |
| 22.297 | 8.312 | 31.326 |
| 22.920 | 3.528 | 22.083 |
| 23.145 | 11.572 | 38.176 |
| 23.334 | 9.682 | 34.957 |
| 23.894 | 10.420 | 36.758 |
| 24.980 | 5.798 | 27.643 |
| 25.153 | 12.956 | 42.899 |
| 25.339 | 3.859 | 23.677 |
| 25.526 | 32.369 | 79.284 |
| 25.740 | 19.787 | 59.123 |
| 25.755 | 12.878 | 43.020 |
| 25.762 | 12.883 | 43.140 |
| 26.790 | 9.925 | 36.974 |
| 27.578 | 6.481 | 29.881 |
| 28.880 | 6.567 | 30.551 |
| 30.066 | 27.814 | 71.119 |
| 30.595 | 35.517 | 85.654 |
| 30.608 | 15.304 | 49.669 |
| 30.665 | 15.332 | 49.533 |
| 30.736 | 15.368 | 47.146 |
| 31.033 | 9.682 | 38.286 |
| 31.137 | 7.136 | 31.326 |
| 31.341 | 31.050 | 76.135 |
| 32.754 | 16.377 | 50.078 |
| 32.964 | 19.786 | 60.757 |
| 34.996 | 17.499 | 53.173 |
| 35.115 | 9.746 | 38.731 |
| 36.316 | 13.071 | 47.276 |
| 36.318 | 19.787 | 61.257 |
| 36.673 | 11.573 | 43.748 |
| 37.501 | 18.751 | 56.604 |
| 39.843 | 37.498 | 86.439 |
| 40.320 | 20.160 | 59.123 |
| 40.384 | 12.362 | 45.107 |
| 40.395 | 31.876 | 76.135 |
| 43.001 | 17.360 | 57.379 |
| 43.513 | 21.757 | 62.783 |
| 44.314 | 19.787 | 63.129 |
| 46.046 | 15.320 | 52.884 |
| 47.160 | 23.579 | 66.152 |
| 48.561 | 16.982 | 54.343 |
| 50.574 | 40.293 | 89.136 |
| 51.366 | 25.683 | 70.128 |
| 51.929 | 23.087 | 69.155 |
| 54.455 | 46.849 | 97.792 |
| 56.271 | 28.135 | 74.412 |
| 56.400 | 25.956 | 74.624 |
| 57.027 | 38.418 | 86.968 |
| 57.419 | 43.796 | 94.046 |
| 58.616 | 23.857 | 70.325 |
| 62.065 | 31.032 | 77.912 |
| 62.948 | 30.157 | 81.408 |
| 66.897 | 32.689 | 85.138 |
| 69.013 | 34.506 | 81.649 |
| 69.250 | 34.624 | 86.968 |
| 69.268 | 27.160 | 69.737 |
| 69.302 | 34.651 | 86.968 |
| 72.094 | 36.024 | 89.972 |
| 72.738 | 49.284 | 93.744 |
| 73.996 | 31.357 | 77.687 |
| 74.840 | 32.940 | 85.138 |
| 77.496 | 38.747 | 88.313 |
| 79.324 | 58.664 | 105.767 |
| 81.111 | 36.450 | 90.253 |
| 86.635 | 39.542 | 94.653 |
| 87.735 | 50.496 | 98.770 |
| 88.094 | 44.047 | 94.348 |
| 95.256 | 61.765 | 107.663 |
| 101.696 | 50.848 | 102.509 |
| 103.314 | 44.520 | 95.267 |
| 106.437 | 44.929 | 89.136 |
| 109.144 | 52.144 | 108.051 |
| 109.832 | 51.608 | 98.442 |
| 111.961 | 60.024 | 106.518 |
| 119.805 | 59.902 | 110.028 |
| 125.936 | 61.544 | 115.525 |
| 132.936 | 70.856 | 114.207 |
| 143.846 | 65.185 | 112.078 |
| 145.092 | 72.544 | 117.792 |
| 149.912 | 74.967 | 126.279 |
| 150.701 | 75.259 | 116.874 |
| 160.672 | 80.339 | 115.525 |
| 163.930 | 81.959 | 122.124 |
| 169.496 | 101.496 | 128.480 |
| 212.445 | 118.085 | 135.658 |
| 241.004 | 114.722 | 140.318 |
| 365.581 | 195.946 | 147.737 |
| 394.787 | 193.131 | 162.154 |
| 416.403 | 216.096 | 154.479 |
| 827.672 | 413.745 | 167.552 |
| 831.636 | 415.870 | 166.430 |
| 847.309 | 423.549 | 162.154 |
| 862.053 | 431.040 | 159.150 |