Avia Leader

Avia Leader

Avia Leader

I have finished my master degree in organic chemistry under the supervision of Prof. Silvio Biali at the Hebrew University. Two topics of my work involved the synthesis and structural characterization. First referred to a modified calix[6]arene hexa-Boc derivative (Boc = tert-butoxycarbonyl) functionalized at the methylene bridges. And second one involved the photochemical bromination reaction, which final product, the octabromo derivative, was determined by the NMR spectrum in the presence of a chiral solvating agent (Pirkle's reagent). On the basis of the number of methoxy signals observed in the presence of the reagent, it was concluded that the kinetic product is one of the achiral forms.

The topic of my Ph.D. studies is to investigate the interactions between the layers, which are made of peptides and nanoparticles, and the bacteria. While the goal of my research is to create a bifunctional coating consisting of antifouling and antimicrobial character. Controlling formation, establishment, and proliferation of microbial biofilms on surfaces is critical for ensuring public safety. Such coatings can support reducing public health issues related to microbial cross-contamination in areas such as food processing, hospitals, and water purification. In addition, we will characterize the bacteria-surface interactions with AFM. This tool will provide quantitative measure of the strength of the interactions and teach us about the properties of the modified surfaces. Briefly, the AFM will be employed similarly to the mode mentioned above by studying the forces needed to detach the bacteria from the surface. We believe that this approach will enable to estimate and compare the antifouling and antimicrobial properties of the coatings.

  • Poms, D., Leader, A., & Biali, S. E. (2015). The kinetic product of the octabromination of p-tert-butylcalix[8]arene octamethyl ether. ARKIVOC, 3, 7-17.‏
  • Leader, A., Itzhak, N., Bogoslavsky, B., & Biali, S. E. (2015). Calix[6]arene   functionalized at four bridges: conformation and intramolecular guest exchange. Eur. J. Org. Chem., 29, 6489-6494.

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