Electrochemically Driven Hydroxyapatite Nanoparticles Coating of Medical Implants.


Geuli O, Metoki N, Eliaz N, Mandler D. Electrochemically Driven Hydroxyapatite Nanoparticles Coating of Medical Implants. Adv. Funct. Mater.Advanced Functional Materials. 2016 :Ahead of Print.

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Calcium phosphates are of great interest for biomedical applications such as bone tissue engineering, bone fillers, drug and gene delivery, and orthopedic and dental implant coating. Here, the first electrochem. driven coating of medical implants using hydroxyapatite (HAp) nanoparticles (NPs) as building blocks is reported. This uncommon combination offers a simple, straightforward, and economic process with well controllable, pure, single-phase HAp. Cryst., pure HAp NPs are formed by pptn. reaction. The HAp NPs are dispersed by either citrate or poly(acrylic acid) to form pH sensitive dispersion. Controllable and homogeneous coating of medical implants is accomplished by altering the pH on the surface upon applying either a const. potential or current. The process involves protonation of the carboxylic acid moieties, which causes the irreversible aggregation of the HAp NPs due to diminishing the repulsive forces between the particles. Deposition is further demonstrated on a com. dental implant. Moreover, the adhesion of the coating satisfies FDA and international std. requirements. A porous interconnected network of bone-like HAp layer is formed during soaking in a simulated body fluid for 30 d and is similar to bone generation, and it therefore holds promise for further in vivo testing. [on SciFinder(R)]


CAPLUS AN 2016:1534906(Journal)