Electrocoating of stainless steel coronary stents for extended release of Paclitaxel.

Citation:

Okner R, Oron M, Tal N, Mandler D, Domb AJ. Electrocoating of stainless steel coronary stents for extended release of Paclitaxel. Mater. Sci. Eng., CMaterials Science & Engineering, C: Biomimetic and Supramolecular Systems. 2007;27 (3) :510 - 513.

Date Published:

2007///

Abstract:

The purpose of this study was to examine chem., mech. and Paclitaxel release properties of the new coating onto the stainless steel coronary stents. Stainless steel coronary stents were coated with elec. polymerizable pyrrole deriv., applying cyclic voltammetry technique in a simple 3 electrode cell, while stent represented a working electrode. Resulted polymer coating were examd. by cyclic voltammetry (elec. parameters), SEM (morphol. images), goniometer (hydrophobisity of the surface), profilometer ( thickness of the polymer coating). Polymer stability was examd. by placing the coated stent into 1:1 soln. of fetal calf serum:seline soln. up to 1 yr and under the mouse skin for 1 wk. Paclitaxel loading were carried out by immersion into drug soln. and its release was detected by HPLC. Reproducible one step method for coating different pyrrole derivs. on stainless steel coronary stents provided thin (single micrometers), uniform coating with various morphol. and hydrophobisity. These surface properties allow to load appropriate amt. of Paclitaxel and to release it slowly up to a month. [on SciFinder(R)]

Notes:

CAPLUS AN 2007:229013(Journal)