Electropolymerized Tricopolymer Based on N-Pyrrole Derivatives as a Primer Coating for Improving the Performance of a Drug-Eluting Stent.

Citation:

Okner R, Shaulov Y, Tal N, Favaro G, Domb AJ, Mandler D. Electropolymerized Tricopolymer Based on N-Pyrrole Derivatives as a Primer Coating for Improving the Performance of a Drug-Eluting Stent. ACS Appl. Mater. InterfacesACS Applied Materials & Interfaces. 2009;1 (4) :758 - 767.

Date Published:

2009///

Abstract:

The coating of medical implants by polymeric films aims at increasing their biocompatibility as well as providing a durable matrix for the controlled release of a drug. In many cases, the coating is divided into a primer layer, which bridges between the medical implant and the drug-eluting matrix. The primer coating must be very carefully designed in order to provide optimal interactions with the surface of the medical implant and the outer layer. Here we present a simple and versatile approach for designing the primer layer based on electropolymn. of a carefully chosen blend of three different pyrrole derivs.: N-methylpyrrole (N-me), N-(2-carboxyethyl)pyrrole (PPA), and the Bu ester of N-(2-carboxyethyl)pyrrole (BuOPy). The compn. and phys. properties of the primer layer were studied in detail by at. force microscopy (AFM) and a nano scratch tester. The latter provides the in-depth anal. of the adhesion and viscoelasticity of the coating. AFM phase imaging reveals a uniform distribution of the three monomers forming rough morphol. This primer layer significantly improved the morphol., stability, and paclitaxel release profile of a paclitaxel-eluting matrix based on Me and lauryl methacrylates. [on SciFinder(R)]

Notes:

CAPLUS AN 2009:300164(Journal)