Enzyme-catalyzed biotransformations through photochemical regeneration of nicotinamide cofactors.

Citation:

Willner I, Mandler D. Enzyme-catalyzed biotransformations through photochemical regeneration of nicotinamide cofactors. Enzyme Microb. Technol.Enzyme and Microbial Technology. 1989;11 (8) :467 - 83.

Date Published:

1989///

Abstract:

A review with 110 refs. on photosensitized regeneration of NAD(P)H cofactors by photochem. means. Reductive regeneration of NAD(P)H cofactors proceeds through coupling of photogenerated N,N'-dimethyl-4,4'-bipyridinium radical cation, which acts as electron carrier, to the enzymes lipoamide dehydrogenase, LipDH and ferredoxin reductase, FDR, resp. Regeneration of NAD(P)H is also accomplished by substitution of the enzymes and electron carrier by synthetic rhodium complexes acting as H-donors for the regeneration of NAD(P)H. Oxidn. of NAD(P)H proceeds either by reductive quenching of the excited photosensitizer by NAD(P)H or dark oxidn. of NAD(P)H by the oxidized photoproduct formed in the photosensitized electron-transfer process. The systems are applied in the dehydrogenation of alcs., hydroxy acids, and amino acids. [on SciFinder(R)]

Notes:

CAPLUS AN 1989:495470(Journal; General Review)