Pyrrole derivatives for electrochemical coating of metallic medical devices.

Citation:

Weiss Z, Mandler D, Shustak G, Domb AJ. Pyrrole derivatives for electrochemical coating of metallic medical devices. J. Polym. Sci., Part A: Polym. Chem.Journal of Polymer Science, Part A: Polymer Chemistry. 2004;42 (7) :1658 - 1667.

Date Published:

2004///

Abstract:

Electropolymn. of medical devices such as cardiovascular stents may possess advantages including a simple and reproducible process with the ability to control the thickness, adherence, and compn. of the coating by the duration and intensity of the applied current, the monomer compn. and concn., the solvent, and the reaction conditions. The properties of the polymer can also be controlled by copolymn. of different monomers, grafting substituents to a functionalized polymer, and by entrapping biomols. This article describes the synthesis of a range of pyrrole-based monomers and their electrocoating onto stainless steel surfaces. N-substituted pyrrole monomers with C1-C18 alkyl chains and polyethylene glycol chains were synthesized in good yields and purity. Electropolymn. of these monomers provided uniform coatings with different hydrophobicities. Studies now focus on the incorporation of drugs in the coated device for release from the surface. [on SciFinder(R)]

Notes:

CAPLUS AN 2004:231437(Journal)