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Solar light induced formation of chiral 2-butanol in an enzyme-catalyzed chemical system.

Citation:

Mandler D, Willner I. Solar light induced formation of chiral 2-butanol in an enzyme-catalyzed chemical system. J. Am. Chem. Soc.Journal of the American Chemical Society. 1984;106 (18) :5352 - 3.

Date Published:

1984///

Abstract:

The photosensitized prodn. of chiral (-)-2-butanol is accomplished in a chem.-enzyme catalyzed-system in which ruthenium-tris-bipyridine, Ru(bipy)32+, photosensitizes the redn. of dimethyl-4,4'-bipyridinium (methylviologen, MV2+), and the sensitizer is recycled by oxidn. of (NH4)3EDTA. The primary reduced photoproduct, MV+·, mediates the redn. of NADP to NADPH in the presence of ferredoxin-NADP reductase. The final step in the cycle involves the redn. of 2-butanone by NADPH in the presence of alc. dehydrogenase. The optical purity of the formed (-)-2-butanol is 100%. The net reaction that corresponds to the redn. of 2-butanone by (NH4)3EDTA is an endoergic process by ∼33 kcal/mol EDTA consumed. [on SciFinder(R)]

Notes:

CAPLUS AN 1984:506872(Journal)