Publications

2016
He L, Wang Q, Mandler D, Li M, Boukherroub R, Szunerits S. Detection of folic acid protein in human serum using reduced graphene oxide electrodes modified by folic-acid. Biosensors & Bioelectronics. 2016;75 :389 - 395.Abstract

The detection of disease markers is considered an important step for early diagnosis of cancer. We design in this work a novel electrochem. sensing platform for the sensitive and selective detection of folic acid protein (FP). The platform is fabricated by electrophoretic deposition (EPD) of reduced graphene oxide (rGO) onto a gold electrode and post-functionalization of rGO with folic acid. Upon FP binding, a significant current decrease can be measured using differential pulse voltammetry (DPV). Using this scheme, a detection limit of 1 pM is achieved. Importantly, the method also allows the detection of FP in serum being thus an appealing approach for the sensitive detection of biomarkers in clin. samples. [on SciFinder(R)]

2015
Liu L, Yellinek S, Tal N, Toledano R, Donval A, Yadlovker D, Mandler D. Electrochemical co-deposition of sol-gel/carbon nanotube composite thin films for antireflection and non-linear optics. JOURNAL OF MATERIALS CHEMISTRY C. 2015;3 (5) :1099-1105.
Ratner N, Mandler D. Electrochemical Detection of Low Concentrations of Mercury in Water Using Gold Nanoparticles. ANALYTICAL CHEMISTRY. 2015;87 (10) :5148-5155.
Peled Y, Krent E, Tal N, Tobias H, Mandler D. Electrochemical Determination of Low Levels of Uranyl by a Vibrating Gold Microelectrode. ANALYTICAL CHEMISTRY. 2015;87 (1, SI) :768-776.
Teodorescu F, Rolland L, Ramarao V, Abderrahmani A, Mandler D, Boukherroub R, Szunerits S. Electrochemically triggered release of human insulin from an insulin-impregnated reduced graphene oxide modified electrode. CHEMICAL COMMUNICATIONS. 2015;51 (75) :14167-14170.
Ratner N, Mandler D. Electrochemical Detection of Low Concentrations of Mercury in Water Using Gold Nanoparticles (vol 87, pg 5148, 2015). ANALYTICAL CHEMISTRY. 2015;87 (14) :7492.
Bera RK, Azoubel S, Mhaisalkar SG, Magdassi S, Mandler D. Fabrication of Carbon Nanotube/Indium Tin Oxide ``Inverse Tandem'' Absorbing Coatings with Tunable Spectral Selectivity for Solar-Thermal Applications. ENERGY TECHNOLOGY. 2015;3 (10) :1045-1050.
Liu L, Yellinek S, Valdinger I, Donval A, Mandler D. Important Implications of the Electrochemical Reduction of ITO. ELECTROCHIMICA ACTA. 2015;176 :1374-1381.
Ling H, Liu L, Lee PS, Mandler D, Lu X. Layer-by-Layer Assembly of PEDOT:PSS and WO3 Nanoparticles: Enhanced Electrochromic Coloration Efficiency and Mechanism Studies by Scanning Electrochemical Microscopy. ELECTROCHIMICA ACTA. 2015;174 :57-65.
Gdor E, Shemesh S, Magdassi S, Mandler D. Multienzyme Inkjet Printed 2D Arrays. ACS APPLIED MATERIALS & INTERFACES. 2015;7 (32) :17985-17992.
Bruchiel-Spanier N, Mandler D. Nanoparticle-Imprinted Polymers: Shell-Selective Recognition of Au Nanoparticles by Imprinting Using the Langmuir-Blodgett Method. CHEMELECTROCHEM. 2015;2 (6) :795-802.
Fam DWH, Azoubel S, Liu L, Huang J, Mandler D, Magdassi S, Tok AIY. Novel felt pseudocapacitor based on carbon nanotube/metal oxides. JOURNAL OF MATERIALS SCIENCE. 2015;50 (20) :6578-6585.
Ratner N, Mandler D. Electrochemical detection of low concentrations of mercury in water using gold nanoparticles. Anal ChemAnalytical chemistry. 2015;87 (10) :5148 - 55.Abstract
The electrochemical detection of mercury in aqueous solutions was studied at glassy carbon (GC) and indium-tin oxide (ITO) electrodes modified by gold nanoparticles (Au NPs). Two methods of modification were used: electrochemical reduction of HAuCl4 and electrostatic adsorption of Au NPs stabilized by citrate. We found that the Au NPs modified surfaces yielded higher sensitivity and sharper and more reproducible stripping peaks of Hg as compared with the bare electrodes. The effect of the modification by Au NPs on the stripping potential was examined. Interestingly, the stripping of Hg on GC and ITO modified by Au NPs occurred at the same potential as on bare GC and ITO, respectively. Only the full coverage of ITO by either electrochemically deposited Au for a long time or by vapor deposition, shifted the stripping potential more positive by ca. 0.4 V to that observed on a bare Au electrode. These and further experiments led us to conclude that the Au NPs served as nucleation sites for the deposition of Hg, whereas the GC or ITO are superior for the stripping of mercury. Hence, a combination of well-defined Au NPs on ITO or GC were found ideal for the electrochemical detection of Hg. Indeed, we achieved a remarkable detection limit of 1 μm·L(-1) of Hg using an ITO surface modified by electrostatically adsorbed Au NPs.[on SciFinder (R)]
Peled Y, Krent E, Tal N, Tobias H, Mandler D. Electrochemical determination of low levels of uranyl by a vibrating gold microelectrode. Anal ChemAnalytical chemistry. 2015;87 (1) :768 - 76.Abstract
In this work we report the sensitive electroanalytical detection of uranium(VI) in aqueous solutions. Uranium commonly exists in aqueous solutions in the form of its oxo ion, uranyl (U(VI)O2(2+)). The detection of uranyl has been accomplished by us through its deposition upon reduction by two electrons to the insoluble UO2 using a bare disk gold macroelectrode and anodic stripping voltammetry (ASV). This gave an unsatisfactory detection limit of ca. 1 × 10(-5) M uranyl. Moreover, the evolution of hydrogen bubbles blocked the electrode surface as a result of water reduction at negative deposition potential (-0.7 V vs Ag/AgCl). The application of a 25 μm diameter Au microwire electrode on which UO2 precipitated at negative potential (-1.2 V) improved substantially the detection limit. Further improvement was accomplished by vibrating the microwire working electrode, which increased the amounts of UO2 deposition due to decreasing the diffusion layer. The effect of the vibrating amplitude and frequency on the electroanalytical response was studied and optimized. Eventually, a detection limit of ca. 1 × 10(-9) M uranyl was achieved using a 5 min deposition time, -1.2 V deposition potential, and vibrating the electrode at frequency of 250 Hz and amplitude of 6 V.[on SciFinder (R)]
Ratner N, Mandler D. Correction to Electrochemical Detection of Low Concentrations of Mercury in Water Using Gold Nanoparticles. Anal ChemAnalytical chemistry. 2015;87 (14) :7492.
Teodorescu F, Rolland L, Ramarao V, Abderrahmani A, Mandler D, Boukherroub R, Szunerits S. Electrochemically triggered release of human insulin from an insulin-impregnated reduced graphene oxide modified electrode. Chem Commun (Camb)Chemical communications (Cambridge, England). 2015;51 (75) :14167 - 70.Abstract
An electrochemical insulin-delivery system based on reduced graphene oxide impregnated with insulin is described. Upon application of a potential pulse of -0.8 V for 30 min, up to 70 ± 4% of human insulin was released into a physiological medium while preserving its biological activity.[on SciFinder (R)]
Gdor E, Shemesh S, Magdassi S, Mandler D. Multienzyme Inkjet Printed 2D Arrays. ACS Appl Mater InterfacesACS applied materials & interfaces. 2015;7 (32) :17985 - 92.Abstract
The use of printing to produce 2D arrays is well established, and should be relatively facile to adapt for the purpose of printing biomaterials; however, very few studies have been published using enzyme solutions as inks. Among the printing technologies, inkjet printing is highly suitable for printing biomaterials and specifically enzymes, as it offers many advantages. Formulation of the inkjet inks is relatively simple and can be adjusted to a variety of biomaterials, while providing nonharmful environment to the enzymes. Here we demonstrate the applicability of inkjet printing for patterning multiple enzymes in a predefined array in a very straightforward, noncontact method. Specifically, various arrays of the enzymes glucose oxidase (GOx), invertase (INV) and horseradish peroxidase (HP) were printed on aminated glass surfaces, followed by immobilization using glutardialdehyde after printing. Scanning electrochemical microscopy (SECM) was used for imaging the printed patterns and to ascertain the enzyme activity. The successful formation of 2D arrays consisting of enzymes was explored as a means of developing the first surface confined enzyme based logic gates. Principally, XOR and AND gates, each consisting of two enzymes as the Boolean operators, were assembled, and their operation was studied by SECM.[on SciFinder (R)]
Liu L, Yellinek S, Tal N, Toledano R, Donval A, Yadlovker D, Mandler D. Electrochemical co-deposition of sol-gel/carbon nanotube composite thin films for antireflection and non-linear optics. J. Mater. Chem. CJournal of Materials Chemistry C: Materials for Optical and Electronic Devices. 2015;3 (5) :1099 - 1105.Abstract
Sol-gel/carbon nanotube (CNT) nano-composite films were electrochem. deposited by applying a neg. potential to a conducting substrate, i.e. indium tin oxide (ITO) and an Ag grid printed on polyethylene terephthalate (PET). The deposition is driven by the local pH rise on the cathode that catalyzes the formation of sol-gel films. The latter serve as a binder and trap for CNTs. The deposition can be well manipulated by the deposition potential and time, and the film can be selectively electrodeposited on the conductive parts of Ag grids printed on PET from an optimized dispersion. The thickness, transmittance, morphol. and hydrophilicity of the films are characterized by profilometry, spectrophotometry, SEM (SEM) and water contact angle, resp. It is further revealed that the electrodeposited sol-gel/CNT composite films have non-linear optical properties and exhibit pronounced antireflective performance (specular reflection < 0.5%) over a visible to long-wave IR range, allowing their potential application as optical materials. [on SciFinder(R)]
Steele TWJ, Mandler D.; 2015. Electroactive bioadhesive compositions.Abstract
The present invention relates to electrochem. initiated bioadhesive compns. comprising biocompatible polymers contg. derivs. of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular. [on SciFinder(R)]
Ratner N, Mandler D. Electrochemical Detection of Low Concentrations of Mercury in Water Using Gold Nanoparticles. Anal. Chem. (Washington, DC, U. S.)Analytical Chemistry (Washington, DC, United States). 2015;87 (10) :5148 - 5155.Abstract
The electrochem. detection of Hg in aq. solns. was studied at glassy C (GC) and In-Sn oxide (ITO) electrodes modified by Au nanoparticles (Au NPs). Two methods of modification were used: electrochem. redn. of HAuCl4 and electrostatic adsorption of Au NPs stabilized by citrate. We found that the Au NPs modified surfaces yielded higher sensitivity and sharper and more reproducible stripping peaks of Hg as compared with the bare electrodes. The effect of the modification by Au NPs on the stripping potential was examd. Interestingly, the stripping of Hg on GC and ITO modified by Au NPs occurred at the same potential as on bare GC and ITO, resp. Only the full coverage of ITO by either electrochem. deposited Au for a long time or by vapor deposition, shifted the stripping potential more pos. by ∼0.4 V to that obsd. on a bare Au electrode. These and further expts. led us to conclude that the Au NPs served as nucleation sites for the deposition of Hg, whereas the GC or ITO are superior for the stripping of Hg. Hence, a combination of well-defined Au NPs on ITO or GC were found ideal for the electrochem. detection of Hg. We achieved a remarkable detection limit of 1 μm/L of Hg using an ITO surface modified by electrostatically adsorbed Au NPs. [on SciFinder(R)]

Pages