@article {2953,
	title = {The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosis.},
	journal = {Dev Cell},
	volume = {12},
	number = {6},
	year = {2007},
	month = {2007 Jun},
	pages = {873-85},
	abstract = {We identify a highly specific mutation (jf18) in the Caenorhabditis elegans nuclear envelope protein matefin MTF-1/SUN-1 that provides direct evidence for active involvement of the nuclear envelope in homologous chromosome pairing in C. elegans meiosis. The reorganization of chromatin in early meiosis is disrupted in mtf-1/sun-1(jf18) gonads, concomitant with the absence of presynaptic homolog alignment. Synapsis is established precociously and nonhomologously. Wild-type leptotene/zygotene nuclei show patch-like aggregations of the ZYG-12 protein, which fail to develop in mtf-1/sun-1(jf18) mutants. These patches remarkably colocalize with a component of the cis-acting chromosomal pairing center (HIM-8) rather than the centrosome. Our data on this mtf-1/sun-1 allele challenge the previously postulated role of the centrosome/spindle organizing center in chromosome pairing, and clearly support a role for MTF-1/SUN-1 in meiotic chromosome reorganization and in homolog recognition, possibly by mediating local aggregation of the ZYG-12 protein in meiotic nuclei.},
	keywords = {Animals, Animals, Genetically Modified, Apoptosis, Caenorhabditis elegans Proteins, Cell Nucleus, Chromosome Pairing, DNA Replication, Gonads, In Situ Hybridization, Fluorescence, Meiosis, Nuclear Envelope, Protein Transport, Receptors, Cytoplasmic and Nuclear, Recombination, Genetic},
	issn = {1534-5807},
	doi = {10.1016/j.devcel.2007.05.004},
	author = {Penkner, Alexandra and Tang, Lois and Novatchkova, Maria and Ladurner, Markus and Fridkin, Alexandra and Gruenbaum, Yosef and Schweizer, Dieter and Loidl, Josef and Jantsch, Verena}
}
