@article {2958,
	title = {Matefin/SUN-1 is a nuclear envelope receptor for CED-4 during Caenorhabditis elegans apoptosis.},
	journal = {Proc Natl Acad Sci U S A},
	volume = {103},
	number = {36},
	year = {2006},
	month = {2006 Sep 5},
	pages = {13397-402},
	abstract = {In Caenorhabditis elegans, the antiapoptotic protein CED-9 is localized at the mitochondria, where it binds the proapoptotic protein CED-4. Induction of apoptosis begins when the proapoptotic protein EGL-1 is expressed and binds CED-9. The binding of EGL-1 to CED-9 releases CED-4 from CED-9 and causes the activation of the caspase CED-3. Upon its release from CED-9, CED-4 rapidly translocates to the nuclear envelope (NE) in a CED-3-independent manner. However, the identity of the NE receptor for CED-4 and its possible role in the execution of apoptosis has remained unknown. Here, we show that the inner nuclear membrane SUN-domain protein matefin/SUN-1 is the NE receptor for CED-4. Our data demonstrate that matefin/SUN-1 binds CED-4 and is specifically required for CED-4 translocation and maintenance at the NE. The role of matefin/SUN-1 in the execution of apoptosis is further suggested by the significant reduction in the number of apoptotic cells in the organism after matefin/SUN-1 down-regulation by RNAi. The finding that matefin/SUN-1 is required for the execution of apoptosis adds an important link between cytoplasmic and nuclear apoptotic events.},
	keywords = {Animals, Apoptosis, Apoptosis Regulatory Proteins, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Calcium-Binding Proteins, Caspases, Down-Regulation, Enzyme Activation, Helminth Proteins, Mitochondria, Nuclear Envelope, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Receptors, Cytoplasmic and Nuclear, Repressor Proteins, RNA Interference},
	issn = {0027-8424},
	doi = {10.1073/pnas.0604224103},
	author = {Tzur, Yonatan B and Margalit, Ayelet and Melamed-Book, Naomi and Gruenbaum, Yosef}
}
