@article {21973,
	title = {Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser},
	journal = {Science},
	year = {2018},
	month = {2018/06/14},
	abstract = {Ultrafast isomerization of retinal is the primary step in photoresponsive biological functions including vision in humans and ion-transport across bacterial membranes. We studied the sub-picosecond structural dynamics of retinal isomerization in the light-driven proton pump bacteriorhodopsin using an x-ray laser. A series of structural snapshots with near-atomic spatial and temporal resolution in the femtosecond regime show how the excited all-trans retinal samples conformational states within the protein binding pocket prior to passing through a twisted geometry and emerging in the 13-cis conformation. Our findings suggest ultrafast collective motions of aspartic acid residues and functional water molecules in the proximity of the retinal Schiff base as a key ingredient for this stereo-selective and efficient photochemical reaction.},
	url = {http://science.sciencemag.org/content/early/2018/06/13/science.aat0094.abstract},
	author = {Nogly, Przemyslaw and Weinert, Tobias and James, Daniel and Carbajo, Sergio and Ozerov, Dmitry and Furrer, Antonia and Gashi, Dardan and Borin, Veniamin and Skopintsev, Petr and Jaeger, Kathrin and Nass, Karol and B{\r a}th, Petra and Bosman, Robert and Koglin, Jason and Seaberg, Matthew and Lane, Thomas and Kekilli, Demet and Br{\"u}nle, Steffen and Tanaka, Tomoyuki and Wu, Wenting and Milne, Christopher and White, Thomas and Barty, Anton and Weierstall, Uwe and Panneels, Valerie and Nango, Eriko and Iwata, So and Hunter, Mark and Schapiro, Igor and Schertler, Gebhard and Neutze, Richard and Standfuss, J{\"o}rg}
}
