@article {1914,
	title = {\&nbsp;The new streptozyme test for streptococcal antibodies. Studies in the value of this multiple antigen test in glomerulonephritis, acute pharyngitis, and acute rheumatic fever},
	journal = {Clinical Pediatrics},
	volume = {14},
	number = {9},
	year = {1975},
	pages = {804-809},
	abstract = {THE DETERMINATION of antistrep- tolysin 0 (ASO) in patients{\textquoteright} sera is most
commonly performed as an aid in the diag- nosis of streptococcal infection and their
sequelae.{\textquoteright} However, because of the differences in immune responses to a variety of
streptococcal exoproducts in rheumatic fever
and glomerulonephritis, it is advantageous to measure the level of more than one
antis trep tococcal antibody, particularly in patients with low or borderline ASO levels. 2.3
The recently developed streptozyme test (A-STZ)l is a two-minute slide hemagglutina- tion procedure which quantitatively meas- ures multiple antibodies to streptococcal exracellular products. The reagents are sheep red blood cells sensitized simultaneously with streptolysin 0 (SLO), deoxyribonuclease B (DNase B), hyaluronidase (H), streptokinase (SK), and nicotinamide adenine dinucleotide
glycohydrolase (NADG). A good correlation
betweenA-STZandASOinseraofrheumatic
fever patients has been demonstrated. In
a comparative study{\textquoteright} of the STZ test with titers obtained with three of the antibody
tests, ASO, ADNase B, and AH, the useful- ness of the streptozyme test for laboratories which perform only the ASO test has been demonstrated. Similar conclusions were drawn in a comparative study in our laboratory. 
his report deals with three main topics: 1) the streptozyme studies done in our laboratories on four of human
categories
sera: control group, acute pyodermal ne-
tients and acute rheumatic fever
patients;
2) the reproducibility and specificity of the
streptozyme test; and 3) the development of ASTZ in rabbits immunized with nonviable
and viable streptococci.},
	author = {S. Bergner-Rabinowitz and S. Fleiderman and Mina Ferne and K. Rabinowitz and Isaac Ginsburg}
}
