@article {1942,
	title = {Mechanisms of biodegradation of staphylococci by leukocyte factors and its modulation\&nbsp;},
	journal = {Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene},
	volume = {251},
	number = {Suppl. 10},
	year = {1981},
	pages = {851-859},
	abstract = {Mechanisms of biodegradation of staphylococci by leukocyte factors and its modulation by serum proteins, inflammatory exudates, polyelectrolytes, antibiotics and by lipoteichoic acid: Relation to chemotaxis and to the survival of bacteria in inflammatory sites
After phagocytosis of opsonized and non-opsonized bacteria by phagocytes, there is fusion of
lysosomes discharge of lysosomal factors into phagosomes and activation of metabolic pathways
leading to the generation of hydrogen peroxide, singlet oxygen, and other oxygen radicals, and
death of the engulfed bacteria. Although much is known today about the mechanism by which
phagocytes kill bacteria following phagocytosis, very little is known about the mechanisms of
biodegradation of the engulfed bacteria. Biodegradation of bacteria within PMN involves action
of lysosomal enzymes, neutral protease collagenases and proteases as well as reactive oxygen
radical and release of these products from phagocytes may lead to destruction of host tissue. The
propagation of chronic inflammatory sequellae following infections with staphylococci may also
be mediated by delayed and immediate hypersensitivity reactions. Degradation of products of
microbes also may diffuse into tissue and the chemotactic properties of these exudates attracts
more phagocytic cells. Inflammatory exudates induced by bacterial infections are rich in acid and
neutral hydrolases of leukocyte origin as well as bacterial products.
The purpose of the present communication is to summarize several years of investigation of the
pathogenesis of staphylococcal lesions with emphasis on the role played by anionic and cationic
polyelectrolytes and degradation products of bacteria in the modulation of leukocyte-bacteria
interactions (10, 14).
},
	author = {Isaac Ginsburg and N. Ne{\textquoteright}eman and Meir Lahav and Michael N. Sela and PG. Quie}
}
