@article {2175,
	title = {MANGANESE AND GLYCINE PROTECT AGAINST ETHANOL INDUCED GASTRIC INJURY IN THE RAT},
	journal = {Gastroenterology},
	volume = {104},
	number = {4},
	year = {1993},
	pages = {134},
	abstract = {Oxygen-derived species are implicated in the pathogenesis of tissue
damage in experimental models such as ethanol-induced gastric injury as
well as in certain clinical conditions. The aim of this study was to
examine the protective effect of manganese and glycine, previously shown
to act as H202 scavengers, on ethanol-induced gastric lesions in
the rat: MnCl2 and glycine (12.5-50mg/rat) were injected s.c up to 6
hours prior to oral administration of 96\% ethanol and the extent of
mucosal damage was evaluated 1 hour later by gross and microscopic
score. Mn and  glycine pre-treatment induced a dose-dependent
inhibition of lesion formation. Maximal protection was observed when
agents were applied 4 hours prior to the insult. Gross damage was also
markedly prevented by pre-treatment with dimethyl-thiourea
(DHTU,75mg/Kg), but not by allopurinol. Mixtures of subtoxic
concentrations of ethanol and H202 were highly lethal for monkey
kidney epithelial cells in culture. Cell killing in this model was
markedly attenuated by catalase and DMTU and to a lesser degree by
Mn+2 . These results imply that ethanol-induced gastric damage may in
part, involve generation of oxygen derived species, independent of the
xanthine oxidase system. Mn+2 and glycine provide marked gastro-
protection, acting possibly as oxygen radical scavengers.
},
	author = {M.  Ligumsky and M. Sestieri and E. Okon and Isaac Ginsburg}
}
