@inbook {2195,
	title = {The Interaction of Staphylococcus aureus with Leukocytes in joint\&nbsp;Lesions: An Ultrastructural Study},
	booktitle = {The Staphylococci (Zentralblatt Fur Bakteriologie, Mikrobiologie Und Hygiene : I. Abteiliung, Supplement 14)},
	year = {1985},
	publisher = {Gustav Fischer Verlag},
	organization = {Gustav Fischer Verlag},
	abstract = {Summary.
Viable Staphylococcus aureus (strain Oxford beta lactamase negative) which had been cultivated either in
the absence or presence of penicillin G (subinhibitory concentrations) were injected into the knee joint of
adult rats. Tissue sections taken five days following the injections and analyzed by an electron microscope
revealed the persistence of apparently intact cell walls within macrophages at the inflammatory sites. The
data suggest that even under penicillin effect the macrophages were capable only of digesting the bacterial
cytoplasmic constituents (plasmolysis) but failed to degrade the bacterial peptidoglycan. The possible role
played by anionic polyelectrolytes, which accumulate at the inflammatory sites, in the inhibition of cell wall
degradation by leukocytes in 1/it/0 and the role played by leukocyte factors in the activation of the bacterial
own autolytic wall enzymes will be discussed.
},
	author = {Isaac Ginsburg and Meir Lahav and J. Goultchin and Milu Sadovnik and E. Kwa and J. Wecke and P. Giesbrech}
}
