@proceedings {2201,
	title = {CATIONIC POLYELECTROLYTES ACTIVATE AUTOLYTIC WALL ENZYMES IN STAPHYLOCOCCUSAUREUS: Modulation by anionic polyelectrolytes in relation to the survivalof bacterial constituents in tissues},
	journal = {The Target of Penicillin},
	year = {1983},
	pages = {341-346},
	abstract = {Introduction. 
Although a wealth of knowledge exists today on the biochemical pathways of
biosynthesis, turnover and autolysis of bacterial cell wall components in
vitro (1, 2), surprisingly very little is actually known about the
mechanisms of biodegradation of microbial constituents in_vivo. One should
differentiate between bactericidal and bacteriolytic processes induced by
leukocytes since killed, but non-degraded, microbial cells may persist
within macrophages to trigger chronic inflammation (3, 4). The present
communication further supports our contention (5, 6) that the degradation
of microbial cell wall components by leukocytes may be due to activation,
by leukocytic cationic proteins, of autolytic wall enzymes rather than to
the direct cleavage of the cells by lysosomal hydrolases. The modulation
of bacteriolysis by anionic polyelectrolytes will be described and
discussed in relation to the pathogenesis of chronic inflammation and
afequelae.

},
	author = {Isaac Ginsburg and Meir Lahav}
}
