@proceedings {2203,
	title = {The role played by leukocyte extracts andinflammatory exudates in the release oflipopolysaccharides from Gram negativebacteria: relation to tissue damageInduced during infections},
	journal = {Perspectives in Inflammation- Future Trends and Developments},
	year = {1977},
	pages = {163-167},
	address = {London},
	abstract = {The role played by bacterial lipopolysaccharides (endotoxins) (LPS) in the
initiation of tissue damage during bacterial infections, is well established.
It is accepted that LPS is released from the invading bacteria following
autolysis, and the interaction of the solubilized LPS with tissues and body
fluids lead to the initiation of the physiological, pharmacological and pathological sequelae seen after infections with Gram negative bacterial.
Previous studies from our laboratories have shown that the binding of
LPS to membranes of RBC is markedly enhanced by heat-labile leukocyte
factors2, and that leukocyte factors are also capable of activating {\textquoteleft}LPS{\textquoteright} for
binding to cell surfaces. Since the {\textquoteleft}activation{\textquoteright} of LPS caused by this factor
\s inhibited by protease inhibitors, it was postulated that proteases present
Hn leukocytes and in inflammatory exudates may enhance tissue damage by
increasing the passive sensitization of mammalian cells by LPS to subsequent
lysis in the presence of antibodies and complement.},
	author = {Isaac Ginsburg and Zvia Duchan and S. Bergner-Rabinowitz and M. Ferne}
}
