@article {1902,
	title = {Immunological and biological nature of antigens of Streptococcus mitis and Streptococcus salivarius},
	journal = {Israel Journal of Medical Sciences},
	volume = {4},
	number = {2},
	year = {1968},
	pages = {236-245},
	abstract = {Extracellular antigens have been isolated from Streptococcus mitis, Streptococcus
salivarius and group A streptococcal cultures grown in a synthetic medium.
Analysis of the antigens was performed by immunoelectrophoretic and double
diffusion techniques using rabbit immune sera. S. mitis cultures produced 10
antigens, S. salivarius six antigens and group A streptococcus 12 antigens, when
tested with their corresponding antisera. S. mitis and S. salivarius antigens had
only one common antigen when tested with antisera to both antigen pools. No
cross reaction was found between the exo-antigens of group A and viridans
streptococci. While the extracellular antigen pool of group A streptococci contained
ribonuclease, deoxyribonuclease, hyaluronidase, diphosphopyridine-nucleotidase,
streptokinase and streptolysin 0, that of S. mitis contained only ribonuclease
and that of S. salivarius contained hyaluronidase and collagenase.
Each of the three streptococcal antigen pools contained a hemosensitizing
factor which sensitized mammalian cells to passive immune kill. Sonicates produced
from the mitis, salivarius and group A streptococcus contained six antigens,
most of which cross reacted with each other. S. mitis sonicates were separated
into six fractions by ion exchange chromatography on ECTEOLA cellulose, and
into three major fractions following gel-filtration on Sephadex 0-200 columns.
Rabbits injected i.v. with sonicates derived from S. mitis developed cardiac
and hepatic lesions which, in some cases, were accompanied by a steep rise in
serum glutamic oxalacetic transaminase, sorbitol dehydrogenase and total lipids.
The relationship of tissue damage to enzyme rise is discussed in relation to the
possible early diagnosis of tissue damage following streptococcal infection.},
	author = {Ruth Finkel and Isaac Ginsburg}
}
@article {1901,
	title = {Cardiac and muscular lesions in mice and rabbits injected with group A streptococcal products},
	journal = {Pathologia et Microbiologia },
	volume = {31},
	year = {1968},
	pages = {233-242},
	author = {Z. Bentwich and Z. Silberstein and J. H. Boss and Isaac Ginsburg}
}
@article {1784,
	title = {Toxic effects induced in rabbits by extracellular products and sonicates of group A streptococci.},
	journal = {Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
	volume = {127},
	number = {4},
	year = {1968},
	pages = {1196-1021},
	abstract = {Rabbits injected with streptococcal extracellular protein (SEP) developed degenerative and infiltrative lesions in the heart and liver, with coagulation necrosis and multinucleated giant cells in the latter organ. The majority of these rabbits also showed elevated levels of glutamic-oxalacetic transaminase, or of sorbitol dehydrogenase, and all showed elevated serum lipids. These biochemical indications of cell injury could be found within 2 to 4 hours after a first injection of SEP. No such biochemical or pathologic effects were found following an injection of heated SEP or a commercially available streptokinase-streptodornase preparation from group C streptococcal culture. In a preliminary fractionation of SEP all the activity was found in a fraction not adsorbed to DEAE cellulose at pH 7.4 (0.05 M P04). The active fraction contained at least five antigens and four of the known streptococcal enzymes. Injection of extracts of sonically disrupted streptococci produced similar biochemical and pathologic changes. There was some cross-reacting material between the sonicates and anti-SEP serum. },
	author = {G. Spira and Z., Silberstein and T. N. Harris and Isaac Ginsburg}
}
@article {1584,
	title = {Experimental arthritis in the rabbit induced by group a streptococcal products},
	journal = {Experientia },
	volume = {24},
	number = {3},
	year = {1968},
	pages = {256-257},
	abstract = {Intraartikul{\"a}re Injektion von Streptolysin-S-freien extrazellul{\"a}ren Produkten der Streptokokken Gruppe A verursacht eine zun{\"a}chst akute, in der Folge aber subkutane Synovitis. Die Ver{\"a}nderungen gleichen denjenigen nach Injektion von Streptolollensonikaten, so dass angenommen wird, ausser Streptolysin S bedingen auch andere streptokokkale Faktoren eine Arthritis.},
	author = {Isaac Ginsburg and Z. Silberstein and G. Spira and Z. Bentwich and J. H. Boss}
}
