@article {25409,
	title = {Polycations and polyanions in SARS-CoV-2 infection},
	journal = {Medical Hypotheses Volume 146},
	volume = {146},
	year = {2021},
	abstract = {We hypothesize that polycations, such as nuclear histones, released by neutrophils COVID-19 aggravate COVID-19 by multiple mechanisms: (A) Neutralization of the electrostatic repulsion between the virus particles and the cell membrane, thereby enhancing receptor-mediated entry. (B) Binding to the virus particles, thereby inducing opsonin-mediated endocytosis. (C) Adding to the cytotoxicity, in conjunction with oxidants, cytokines and other pro-inflammatory substances secreted by cells of the innate immunity system. These effects may be alleviated by the administration of negatively charged polyanions such as heparins and heparinoids.},
	url = {https://www.sciencedirect.com/science/article/pii/S0306987720333612?via\%3Dihub},
	author = {Issac Ginsburg and Fibach, Eithan}
}
