The Batsheva Kerem group is focusing on Cancer Research and Personalized medicine approaches for Cystic Fibrosis.
Cancer Research
Genomic instability is a major driving force of tumorigenesis. Our goal is to understand the mechanisms underlying genomic instability during cancer development, with a focus on the role of oncogene and tumor suppressor-affected networks, in DNA replication stress, transcription and chromatin remodeling.
Personalized medicine approaches for Cystic Fibrosis
We aim to develop novel therapeutic approaches for Cystic Fibrosis patients carrying splicing and nonsense mutations, who cannot benefit from the current approved CFTR modulators. This includes antisense oligonucleotides able to modulate correct processing of the CFTR transcripts and small molecules affecting their stability.