@article {2328,
	title = {Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases.},
	journal = {Nat Neurosci},
	volume = {17},
	number = {12},
	year = {2014},
	month = {2014 Dec},
	pages = {1655-7},
	abstract = {Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.},
	keywords = {Animals, Brain, Cocaine, Cocaine-Related Disorders, Enzyme Activation, Male, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Neuronal Plasticity, Organ Culture Techniques, Rats, Rats, Sprague-Dawley, Recurrence, Self Administration},
	issn = {1546-1726},
	doi = {10.1038/nn.3846},
	author = {Smith, Alexander C W and Kupchik, Yonatan M and Scofield, Michael D and Gipson, Cassandra D and Wiggins, Armina and Thomas, Charles A and Kalivas, Peter W}
}
