Continues administration of Nano-PSO significantly increased survival of genetic CJD mice.

Citation:

Binyamin O, Keller G, Frid K, Larush L, Magdassi S, Gabizon R. Continues administration of Nano-PSO significantly increased survival of genetic CJD mice. Neurobiol. Dis.Neurobiology of Disease. 2017;108 :140 - 147.

Date Published:

2017///

Abstract:

We have shown previously that Nano-PSO, a nanodroplet formulation of pomegranate seed oil, delayed progression of neurodegeneration signs when administered for a designated period of time to TgMHu2ME199K mice, modeling for genetic prion disease. In the present work, we treated these mice with a self-emulsion formulation of Nano-PSO or a parallel Soybean oil formulation from their day of birth until a terminal disease stage. We found that long term Nano-PSO administration resulted in increased survival of TgMHu2ME199K lines by several months. Interestingly, initiation of treatment at day 1 had no clin. advantage over initiation at day 70, however cessation of treatment at 9 mo of age resulted in the rapid loss of the beneficial clin. effect. Pathol. studies revealed that treatment with Nano-PSO resulted in the redn. of GAG accumulation and lipid oxidn., indicating a strong neuroprotective effect. Contrarily, the clin. effect of Nano-PSO did not correlate with redn. in the levels of disease related PrP, the main prion marker. We conclude that long term administration of Nano-PSO is safe and may be effective in the prevention/delay of onset of neurodegenerative conditions such as genetic CJD. [on SciFinder(R)]