On the factors affecting the yield of preparation and stability of multiple emulsions.

Citation:

Magdassi S, Frenkel M, Garti N. On the factors affecting the yield of preparation and stability of multiple emulsions. J. Dispersion Sci. Technol.Journal of Dispersion Science and Technology. 1984;5 (1) :49 - 59.

Date Published:

1984///

Abstract:

Multiple (water-in-oil-in water) emulsions were prepd. by homogenizing 30 parts 1% NaCl with 70 parts of light mineral oil contg. varying amts. of Brij 92 emulsifier and then adding 20 parts of this primary emulsion to 80 parts of 5% glucose contg. varying amts. of mixts. of Span 20 [1338-39-2] and Tween 80 [9005-65-6] to provide hydrophile-lipophile balance (HLB) values of 9-15. At Tween-Span emulsifier mixt. concns. of 0.7-1.5% the yield of multiple emulsion was not affected by HLB value; droplet size detd. the yield. At emulsifier concns. >1.5% the yield decreased with increasing concn. at any HLB, related to a continuous decrease in multiple emulsion droplet size. Yields and emulsion stability were max. with an HLB value of 11 at emulsifier concns. >1.5%; at emulsifier mixt. concns. of 0.7-3% stability increased with increasing HLB value. Multiple emulsions are promising pharmaceutical forms. [on SciFinder(R)]

Notes:

CAPLUS AN 1984:497528(Journal)