Formation of curcumin nanoparticles by flash nanoprecipitation from emulsions


Margulis K, Magdassi S, Lee HS, Macosko CW. Formation of curcumin nanoparticles by flash nanoprecipitation from emulsions. Journal of Colloid And Interface Science [Internet]. 2014;434 :65 - 70.

Date Published:

2014/11/15/15 No


•A new method for production of organic nanoparticles is demonstrated for curcumin.•The method is based on flash nanoprecipitation from partially water-soluble emulsions.•A simple hand-operated mixer is employed for flash nanoprecipitation process.•Dry nanometric powders obtained by spray drying are easily dispersible in water.•The resultant particles are 40nm in diameter and contain above 20wt% active substance.Nanometric particles of a model hydrophobic substance curcumin were prepared by a novel method, namely, flash nanoprecipitation from a coarse oil-in-water emulsion. The method employs turbulent co-mixing of water with curcumin-loaded emulsion using manually-operated confined impingement jets mixer. A clear and stable dispersion of nanoparticles was formed in this process, and could be converted to dry, easily water-dispersible powder by spray drying. The mean size of the particles was about 40nm by DLS, confirmed by Cryo-TEM. The obtained particles contained 20.4wt% curcumin, X-ray analysis showed it was amorphous. The significant advantages of the studied process are its feasibility, speed and low cost. It does not require any special high-energy input equipment to reduce the droplet size of the initial emulsion as required by the vast majority of other methods, and relies on rapid turbulent mixing and on flow-induced shear stress formed in the simple, manually-operated mixer. Control experiments clearly indicate that employing emulsion, instead of a plain solution and flash nanoprecipitation instead of a simple antisolvent precipitation are advantageous in terms of particle size and stability.


Accession Number: S0021979714005384; Author: Margulis, Katherine (a, ⁎); Author: Magdassi, Shlomo (a); Author: Lee, Han Seung (b); Author: Macosko, Christopher W. (b); Affiliation: Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; Affiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA; Number of Pages: 6; Language: English;