Formation of Organic Nanoparticlesby Electrospinningof Volatile Microemulsions.


Dvores MP, Marom G, Magdassi S. Formation of Organic Nanoparticlesby Electrospinningof Volatile Microemulsions. Langmuir [Internet]. 2012;28 (17) :6978 - 6984.

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This study presents a method for one-step formation ofpoly(ethyleneoxide) nanofibers incorporating nanoparticles of a poorly water-solublecompound. Using the new method reported here, nanofiber–nanoparticlecomposites are fabricated in one step by electrospinning of an oil-in-watermicroemulsion, in which a model material, propylparaben, has beendissolved within the volatile dispersed phase in the presence of ahigh-molecular-weight polymer. The approach is based on nanoscaleconfinement to the dispersed phase of an oil-in-water microemulsionwith a volatile oil phase, in which the poorly water-soluble materialsare dissolved. Thus, when the thermodynamically stable oil-in-watermicroemulsion is combined with the rapid evaporation of solvent inherentin the electrospinning process, the droplets are converted into organicnanoparticles embedded within a polymeric nanofiber. In addition topossessing process simplicity, this method exhibits a very high percentageof nanoparticle loading with desirable active material properties.Specifically, the diameter of the nanofibers is in the range of 60–185nm, and propylparaben exists within the nanofiber as nanocrystalsof 30–120 nm. These dimensions suggest that the nanofiber–nanocrystalcomposites could serve as a delivery system for water-insoluble materials. [ABSTRACT FROM AUTHOR]Copyright of Langmuir is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)


Accession Number: 74760293; Dvores, Michelle P. 1 Marom, Gad 1 Magdassi, Shlomo 1; Affiliation: 1: Casali Institute of Applied Chemistry, The Institute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904,Israel; Source Info: May2012, Vol. 28 Issue 17, p6978; Subject Term: MICROEMULSIONS; Subject Term: VOLATILE organic compounds; Subject Term: ELECTROSPINNING; Subject Term: NANOPARTICLES; Subject Term: ORGANIC chemistry; Subject Term: MOLECULAR weights; Subject Term: NANOFIBERS; Number of Pages: 7p; Document Type: Article