A nanoformulated trinuclear hydrolysis product of a bis(alkoxo) salan-Ti(IV) complex shows high antitumor activity, which identifies it as an active species in cells. Additional highly stable mononuclear derivatives also show high activity, when formulated into nanoparticles, thus evincing that biologically friendly Ti(IV) can provide high cytotoxicity with controlled biological function.; Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Accession Number: 22961758. Language: English. Date Revised: 20131121. Date Created: 20121010. Date Completed: 20130521. Update Code: 20141125. Publication Type: Journal Article. Journal ID: 0370543. Publication Model: Print-Electronic. Cited Medium: Internet. NLM ISO Abbr: Angew. Chem. Int. Ed. Engl.. Linking ISSN: 14337851. Subset: IM; Date of Electronic Publication: 2012 Sep 07. Current Imprints: Publication: <2004-> : Weinheim : Wiley-VCH; Original Imprints: Publication: Weinheim/Bergstr. : New York, : Verlag Chemie ; Academic Press, c1962-