Near infrared fluorescent particles and uses thereof.


Magdassi S, Lazarovici P, Larush L, Portnoy E, Lecht S, Tivony R.; 2012. Near infrared fluorescent particles and uses thereof.


The present invention provides particles comprising either a water-sol. polymer or a phospholipid, wherein at least one near-IR (NIR) fluorescent probe and optionally at least one active agent such as a targeting moiety, capable of selectively recognizing a particular cellular marker, are non-covalently bound to the outer surface of the particles. Pharmaceutical compns. comprising these particles may be used, inter alia, for detection and treatment of tumors in the gastrointestinal tract. Anti-CEA-FITC-labeled indocyanine green (ICG)-adsorbed Eudragit RS-casein sodium salt polycationic nanoparticles were prepd. and used for in vivo specific recognition in and imaging of colons of LS174T tumor-bearing mice. Well identified LS174T tumors were successfully marked by the nanoparticles. [on SciFinder(R)]


CAPLUS AN 2012:379915(Patent)