Publications by Type: Patents

2005
Magdassi S, Eron G, Vinetsky Y.; 2005. Ink for ceramic surfaces.Abstract
The present invention concerns ink for printing on ceramic surfaces such as glass, which contains glass frits for silica nanoparticles and optionally a pigment beside ordinary components such as binders, pigments, additives and solvents, and is suitable for ink jet printing. A such ink will fuse to the substrate upon firing, and is characterized by: (a) having viscosity bellow 20 cPs at jetting temp. and (b) becoming an integral part of the substrate upon exposure to temps. above 500°. [on SciFinder(R)]
Tawfik D, Bernath K, Aharoni A, Peisajovich S, Griffiths AD, Mastrobattista E, Magdassi S.; 2005. Methods for in vitro sorting of molecular and cellular libraries, such as a gene library, that are microencapsulated using water-in-oil-in-water emulsions.Abstract
The present invention provides an in vitro system for compartmentalization of mol. or cellular libraries and provides methods for selection and isolation of desired mols. or cells from the libraries. The library includes a plurality of distinct mols. or cells encapsulated within a water-in-oil-in-water (w/o/w) emulsion. The emulation includes a continuous external aq. phase and a discontinuous dispersion of water-in-oil droplets. The internal aq. phase of a plurality of such droplets comprises a specific mol. or cell that is within the plurality of distinct mols. or cells of the library. According to a first aspect the present invention provides a gene library comprising a plurality of re-emulsified water-in-oil droplets, each droplet comprises an external water phase surrounding a central water-in-oil droplet, the internal water phase within each droplet comprises a genetic element, in vitro transcription-translation reaction system. To ensure that the genetic elements and gene products may not diffuse between primary water-in-oil droplets or between re-emulsified water-in-oil droplets, the-contents of each droplet must be isolated from the contents of the surrounding droplets, so that there is no or little exchange of gene products between the droplets over the timescale of the expt. The method of the present invention requires that there are only a limited no. of genetic elements per droplet. This ensures that the gene product of an individual genetic element will be isolated from other genetic elements. Finally, the formation and the compn. of the droplets must not interrupt with the function of the expression machinery of the genetic elements and the activity of the gene products. Prepn. and sorting of w/o/w emulsions by FACS (fluorescence-activated cell sorting) were demonstrated using lacZ reporter selection from a pool of lacZ gene mutants. Compartmentalization and detection of PON1 (serum paraoxonase) gene variants in single Escherichia coli cells were also demonstrated. [on SciFinder(R)]
Magdassi S, Spernath L.; 2005. Preparation of nanoparticles from nanoemulsions and nanoparticles of an active agent.Abstract
The prodn. of nanoparticles from oil-in-water nanoemulsions, occurs by phase inversion techniques. The phase inversion may be achieved by using a const. temp., where the inversion occurs by continuous addn. of H2O or by varying the temp. involving heating and rapid cooling. More specifically, the process comprises (a) mixing the active agent (e.g. monomer) with a volatile solvent and ≥1 nonionic surfactant, (b) adding to the mixt. of (a) an aq. phase to form a water-in-oil emulsion, (c) continuously adding to the emulsion of (b) water at a rate enabling phase inversion and formation of oil-in-water nanoemulsion, (d) evapg. the volatile solvent from the oil-in-water nanoemulsion of (c) to obtain nanoparticles. The formation of lauryl acrylate polymer nanoparticles was demonstrated in the presence of Brij 96v. [on SciFinder(R)]
2004
Magdassi S, Kahana F, Nini D, Zegerman C, Itach I.; 2004. Matrix with aroma for multiple openings of a package.Abstract
The invention concerns a method for providing a lasting aroma-impact of packaged goods which is sustained even after multiple open and closing cycles, by attaching to the package a solid or semi-solid matrix having the aroma fraction dispersed, entrapped, encapsulated or embedded in the matrix. The matrix in accordance with the invention is adapted to controlled ,slow release of the aroma fraction, e.g. a coffee aroma fraction. [on SciFinder(R)]
Desai NP, Tao C, Yang A, Louie L, Yao Z, Soon-Shiong P, Magdassi S.; 2004. Protein stabilized pharmacologically active agents, methods for the preparation thereof, and methods for the use thereof.Abstract
In accordance with the present invention, there are provided compns. and methods useful for the in vivo delivery of substantially water insol. pharmacol. active agents (such as the anticancer drug paclitaxel) in which the pharmacol. active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacol. active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diam. of less than about 1 μ. The use of specific compn. and prepn. conditions (e.g., addn. of a polar solvent to the org. phase), and careful election of the proper org. phase and phase fraction, enables the reproducible prodn. of unusually small nanoparticles of less than 200 nm diam., which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insol. drug coated with a protein, and free protein to which mols. of the pharmacol. agent are bound. This results in a unique delivery system, in which part of the pharmacol. active agent is readily bioavailable (in the form of mols. bound to the protein), and part of the agent is present within particles without any polymeric matrix therein. [on SciFinder(R)]
2003
Magdassi S, Kamyshny A, Vinetsky Y, Bassa A, Abo Mokh R.; 2003. Ink-jet inks containing metal nanoparticles useful for conductive patterns.Abstract
Compns. for use in ink jet printing onto a substrate comprise a water based dispersion including metallic nanoparticles and appropriate stabilizers. Also disclosed are methods for the prodn. of said compns. and methods for their use in ink jet printing onto suitable substrates. Thus, an ink comprised 99.75% nanoparticle dispersion comprising 0.18% silver nanoparticle and 0.2% CM-cellulose sodium salt and 0.25% BYK 154 wetting agent. [on SciFinder(R)]
Magdassi S, Yang A, Tao C, Desai NP, Yao Z, Soon-Shiong P.; 2003. Preparation of total nutrient admixtures as stable multicomponent liquids or dry powders.Abstract
Stabilized total nutrient admixt. (TNA) compns., useful for the in vivo parenteral delivery of pharmacol. acceptable lipids or fats, as well as methods for their prepn. are described. In particular, the pharmacol. acceptable lipid or fat is contained within a biocompatible polymer, e.g., a protein, walled shell. In a particular embodiment of the invention, a TNA compn. using human serum albumin (HSA) as a stabilizer has been prepd. as a convenient three-in-one formulation (i.e., contg. a fat emulsion, dextrose, and amino acids plus electrolytes). This "three-in-one" formulation can be prepd. in liq. form or in dry form (comprising submicron-sized nanoparticles). The dried material is stable, even under long term storage, and is easily reconstituted immediately before use by simply adding sterile water (with or without vitamin supplementation). This serves to rehydrate the powder into a TNA suitable for injection. The long shelf life, ease of reconstitution, and single-component injectability of invention compns. provide significant cost savings, as such compns. can be reconstituted and administered safely, even at home. In addn., HSA, the stabilizing agent of choice for use in the practice of the present invention, has been shown to improve survival and wellness when given as a supplement to patients receiving conventional forms of total nutrient admixts. [on SciFinder(R)]
Kamyshny A, Magdassi S, Mishirqi S.; 2003. Diagnostic beads for the detection of blood in animal excreta and a method for production thereof.Abstract
Diagnostic beads are disclosed for the detection of occult blood in animal excreta, esp. for use in a cat litter. The beads comprise a particulate material and a detection compn. attached to the particulate material. The detection compn. comprises a chromogen, a peroxide, an enhancer, a stabilizer, and a binder, the chromogen being selected to react with occult blood in the animal excreta so as to produce a visible and immediate color change when excreta contg. blood comes into contact with the diagnostic beads. [on SciFinder(R)]
Steinberg D, Kamyshny A, Magdassi S.; 2003. Edible compositions capable of removing oral biofilm.Abstract
An edible and/or chewable article contg. at least one food grade substance having adsorption affinity towards at least one dental plaque (biofilm) constituent and capable of reducing and/or removing the oral biofilm while present in the mouth is described. Particular articles are chewing gums, sweets, candies, candy- and other nutritional bars, ice creams, chocolates, confectionery and bakery/pastry products, honey, dairy products and beverages, and oral hygiene products such as tooth pastes, oral gels and mouthwashes. A chewing gum comprises a conventional gum base and at least one food grade active substance having adsorption affinity towards at least one dental plaque (biofilm) constituent (bacteria and proteins and bacterial cell-free enzymes) and capable of reducing and/or removing the oral biofilm while present in the mouth. Typical active substances are polysaccharides and non-toxic salts thereof, such as alginates, chitosan, CM-cellulose, agar and carrageenan, inorg. substances such as silica, hydroxyapatite and calcium carbonate, and proteins, particularly gelatin and lectin. The chewing gum and other articles are particularly intended for removing and/or for preventing or reducing dental plaque (biofilm), and controlling oral, dental and periodontal diseases. For example, chewing gum base contg. sodium alginate exhibited high binding properties for Streptococcus mutans, av. of 2000% compared to the gum base without the alginate (control = 100% adhesion). Other polysaccharides, such as carrageenan, agar, sodium CM-cellulose and chitosan also exhibited higher adsorption than the control chewing gum base, but less than the alginate (500%, 510%, 600%, and 400%, resp.). [on SciFinder(R)]
2002
Lapidot N, Magdassi S, Avnir D, Rottman C, Gans O, Seri-Levy A.; 2002. Stable formulation of topically active ingredients.Abstract
A therapeutic, cosmetic or cosmeceutic compn. for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprises a plurality of microcapsules having a core-shell structure. The microcapsules have a diam. of approx. 0.1 to 100 μ. The core of each microcapsule includes at least one active ingredient and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorg. polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The compn. is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin. Me salicylate were mixed with tetraethoxysilane (TEOS). The org. phase was emulsified in an aq. soln. contg. 1% cetyltrimethyl ammonium chloride (CTAC) under high shear. This emulsion was then poured into a reactor contg. aq. NaOH soln. at pH 11.5. The soln. was stirred and after 7 days the product was pptd. in a centrifuge. The final product was re-suspended in water contg. 1% polyvinylpyrrolidone to receive a suspension contg. 32.4% Me salicylate encapsulated in silica particles of 0.5-10 μ. [on SciFinder(R)]
Lapidot N, Magdassi S, Avnir D, Rottman C, Gans O, Seri-Levy A.; 2002. Sunscreen composition containing sol-gel microcapsules.Abstract
The present invention generally relates to safe and stable sunscreen compns. comprising of at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating UV absorbing compds. in any acceptable cosmetic vehicle. The compn. according to the present invention can comprise several UV absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The hydrophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen compn., thus, the present invention facilitates an easy incorporation of the composite sol-gel encapsulated sunscreen in all types of cosmetic vehicles including oil free compns., with no necessary steps of heating or high shear forces. The sunscreen compns. of the present invention can comprise any acceptable UVA and/or UVB absorbing compds. at any desired ratio to obtain a desired accumulative UV screening spectrum. An aq. suspension of silica microcapsules, contg. 35.8% p-methoxycinnamate (OMC) was prepd. An oil in water emulsion contg. liq. paraffin (mineral oil) 5.00, decyl oleate 5.00, dimethicone 1.00, cetearyl alc. 1.00, glyceryl stearate 3.00, potassium cetyl phosphate 2.00, water 47.25, xanthan gum 0.15, propylene glycol 5.00, 2-bromo-2-nitropropane-1,3-diol & methylparaben & phenoxyethanol & propylbaraben 5.00, 88% lactic acid 0.10, and above silica/OMC (25% OMC in water suspension) 30.00%. [on SciFinder(R)]
2001
Magdassi S, Ben-Moshe M.; 2001. Ink-jet ink compositions based on oil-in-water microemulsion forming nanoparticles upon application on a surface.Abstract
An ink-jet ink compn. for piezoelec. in-jet printing comprises: (a) a hydrophobic dye; (b) an oil-in-water microemulsion including: (i) a volatile oil; (ii) water; (iii) a co-solvent; (iv) at least one surfactant; and (v) a binder, wherein upon application of the ink to a substrate surface, the volatile oil evaps. and nanoparticles are formed. The invention addnl. discloses a printing process using the ink compn. [on SciFinder(R)]
Lapidot N, Magdassi S, Avnir D, Rottman C, Gans O, Seri-Levy A.; 2001. Inorganic polymer-based microcapsules with enhanced formulation stability and delivery of topical active ingredients.Abstract
A therapeutic or cosmetic compn. for topical application, capable of stabilizing an active ingredient and delivering said ingredient, comprising a plurality of microcapsules having a core-shell structure and a diam. of approx. 0.1-100 μ. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorg. polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and releases the ingredient after topical application. This compn. is useful to encapsulate active ingredients that are unstable in formulation, or are irritating to the skin. The present invention further discloses a process for the encapsulation of an active ingredient in the form of a dispersion within a hydrophobic phase. For example, combinations of erythromycin and benzoyl peroxide are useful in the treatment of acne but usually must be formulated as a two component system because of incompatibility of the two active ingredients. Thus, erythromycin was encapsulated in silica; 1.7 g of erythromycin was mixed with 14.9 g of octylmethoxy cinnamate, and 19.5 g of tetraethoxy silane (TEOS) was added. This oil phase was emulsified and the emulsion was poured into a basic soln. of pH 11.5. The mixt. was stirred at 50-240 rpm. Flocculation was induced by the addn. of MgSO4 at a final concn. of 0.1% by wt. The ppt. was collected by filtration and a product obtained was a paste with a particle size distribution of 1-12 μ (an av. size of 6.2 μ). Encapsulation of benzoyl peroxide (30 g of 7% soln. in diisopropyl sebacate) was carried out by mixing it with 20 g of TEOS. The org. phase was emulsified in 200 g of an aq. soln. contg. 1% CTAC under high shear. The emulsion obtained was poured into a reactor contg. 200 g NaOH aq. soln. at pH 10 and stirred. The final product was re-suspended in water to obtain a dispersion contg. a 3% benzoyl peroxide encapsulated in silica particles of 0.5015 μ. [on SciFinder(R)]
2000
Lapidot N, Magdassi S, Avnir D, Rottman C, Gans O, Seri-Levy A.; 2000. A method for obtaining photostable sunscreen compositions.Abstract
The present invention relates to a method for obtaining improved photostability of a sunscreen compn. that contains at least two sunscreen active ingredients, which are photo-unstable when formulated together, by microencapsulating at least one of said active ingredients in an encapsulating material suitable for holding the encapsulated active ingredient material, thus reducing or preventing its leaching out of the capsules; and adding other acceptable components and additives needed for the prepn. of said compn. The sunscreen active ingredients can be selected from UVA and UVB absorbers, preferably a combination thereof. In a preferred embodiment of the present invention said active ingredients are encapsulated in sep. sol-gel microcapsules. Examples are given for prepn. of microcapsules by a sol-gel method and an oil-in-water sunscreen compn. contg. encapsulated sunscreen actives. [on SciFinder(R)]
Lapidot N, Magdassi S, Avnir D, Rottman C, Gans O, Seri-Levy A.; 2000. Sunscreen composition containing sol-gel microcapsules.Abstract
The present invention generally relates to safe and stable sunscreen compns. comprising at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating UV absorbing compds. in any acceptable cosmetic vehicle. The compn. according to the present invention can comprise several UV absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The encapsulation of the UV absorbers reduces or even prevents the contact between the sunscreen compds. and the human tissue, thus reducing various adverse effects that are assocd. with the use of sunscreens. The encapsulation also reduces or even prevents cross reactivity between the sunscreen compds. and the packaging material and between the sunscreen compds. and any other component present in the compn., thus enhancing the compns. stability. The hydrophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen compn. The sunscreen compns. of the present invention can comprise any acceptable UVA and/or UVB absorbing compds. at any desired ratio to obtain a desired accumulative UV screening spectrum. [on SciFinder(R)]
Maor Z, Yehuda S, Magdassi S, Meshulam-Simon G, Gavrieli Y, Gilad Z, Efron D.; 2000. Cream composition comprising dead sea mud.Abstract
The present invention relates to a pharmaceutical cream composition for topical application for the treatment of skin disorders and skin diseases, comprising 1-6 wt.% Dead Sea Mud as an active ingredient. Said composition is for use in treating skin disorders and skin diseases such as psoriasis, saborrehic dermatitis, xerosis, atopic dermatitis, eczema, diaper rash, skin burns of state I and sensitive skin. Said cream composition is also for use as a leave-on cosmetic cream for beautifying and enhancing the skin appearance. In addition to Dead Sea Mud said composition comprises ingredients suitable for the preparation of cosmetic cream. Said cream can further comprise up to 4 wt.% Dead Sea water. [on SciFinder(R)]
Lapidot N, Magdassi S, Avnir D, Rottman C, Gans O, Seri-Levy A.; 2000. A method for obtaining photostable sunscreen compositions.Abstract
The present invention relates to a method for obtaining improved photostability of a sunscreen compn. that contains at least two sunscreen active ingredients, which are photo-unstable when formulated together, by microencapsulating at least one of said active ingredients in an encapsulating material suitable for holding the encapsulated active ingredient material, thus reducing or preventing its leaching out of the capsules; and adding other acceptable components and additives needed for the prepn. of said compn. The sunscreen active ingredients can be selected from UVA and UVB absorbers, preferably a combination thereof. In a preferred embodiment of the present invention said active ingredients are encapsulated in sep. sol-gel microcapsules. Examples are given for prepn. of microcapsules by a sol-gel method and an oil-in-water sunscreen compn. contg. encapsulated sunscreen actives. [on SciFinder(R)]
Magdassi S, Avnir D, Seri-Levy A, Lapidot N, Rottman C, Sorek Y, Gans O.; 2000. Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof.Abstract
The present invention relates to a novel process for prepg. sol-gel microcapsules loaded with up to 95 % (wt./wt.) functional mols. or substances and to the products obtained by said process. Said process is conducted in two steps: (a) creating an oil-in-water emulsion by emulsification of a water insol. soln. comprising the sol-gel precursors and the mols. to be loaded, in an aq. soln. under appropriate shear forces; (b) mixing and stirring said emulsion with an aq. soln. at a suitably selected pH to obtain loaded sol-gel microcapsules in suspension. The microcapsules so obtained can further be subjected to cycles of isolation and rinsing. Incorporation of the final product, either in the form of a suspension or a powder, in cosmetic formulations affords a transparent cream when applying to skin and has a smooth and pleasant contact. [on SciFinder(R)]
Shani A, Magdassi S, Yosha I.; 2000. Polymer-based water-insoluble beads for sustained release of insect pheromones.Abstract
The invention provides a sustained release, polymer-based, water insol. bead, comprising a polymeric matrix contg. a plurality of emulsion droplets, the droplets being formed from at least one surface-active mol., at least one volatile hydrophobic component and water, wherein the volatile component is released from the water-insol. bead in atm. air. The volatile components are insect pheromones or essential oils. [on SciFinder(R)]
Desai NP, Tao C, Yang A, Louie L, Yao Z, Soon-Shiong P, Magdassi S.; 2000. Preparation of protein-stabilized pharmaceuticals.Abstract
Compns. and methods useful for the in vivo delivery of water-insol. drugs (e.g., anticancer paclitaxel) in which the drug agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizer) are described. In particular, protein and the drug in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diam. of <1 μ. The use of specific compn. and prepn. conditions (e.g., addn. of a polar solvent to the org. phase), and careful election of the proper org. phase and phase fraction, enables the reproducible prodn. of unusually small nanoparticles of less than 200 nm diam., which can be sterile-filtered. The particulate system produced can be converted into a redispersible dry powder comprising nanoparticles of water-insol. drug coated with a protein, and free protein to which mols. of the drug are bound. This results in a unique delivery system, in which part of the drug is readily bioavailable (in the form of mols. bound to the protein), and part of the drug is present within particles without any polymeric matrix. Thus, 20 mg paclitaxel is dissolved in 1.0 mL methylene chloride and the soln. mixed with 4.0 mL human serum albumin soln. The mixt. was homogenized in order to form a crude emulsion and then sonicated. The dispersion was further lyophilized for 48 h without adding any cryoprotectant. The particle size after reconstitution was the same as before lyophilization. [on SciFinder(R)]

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