Publications by Year: 2012

2012
Briand D, Mattana G, Molina-Lopez F, Courbat J, de Rooij NF, Grouchko M, Magdassi S. Printed temperature and humidity sensors on paper. LOPE-C, 2012. 2012.
Kamyshny A, Magdassi S. Inkjet ink formulations. In: Korvink J, Shin D-Y, Smith P Inkjet-based Micromanufacturing. Wiley-VCH ; 2012. pp. 173-189.
Silberstein T, Lutz R, Magdassi S, Tzadok B.; 2012. Natural formulations comprising plant extract.Abstract
The present invention provides an all natural compn. comprising naturally-obtained plant exts. Exts. of Sapindus mukorossi was prepd. and used in a cosmetic compn. for skin care. [on SciFinder(R)]
Magdassi S, Lazarovici P, Larush L, Portnoy E, Lecht S, Tivony R.; 2012. Near infrared fluorescent particles and uses thereof.Abstract
The present invention provides particles comprising either a water-sol. polymer or a phospholipid, wherein at least one near-IR (NIR) fluorescent probe and optionally at least one active agent such as a targeting moiety, capable of selectively recognizing a particular cellular marker, are non-covalently bound to the outer surface of the particles. Pharmaceutical compns. comprising these particles may be used, inter alia, for detection and treatment of tumors in the gastrointestinal tract. Anti-CEA-FITC-labeled indocyanine green (ICG)-adsorbed Eudragit RS-casein sodium salt polycationic nanoparticles were prepd. and used for in vivo specific recognition in and imaging of colons of LS174T tumor-bearing mice. Well identified LS174T tumors were successfully marked by the nanoparticles. [on SciFinder(R)]
Magdassi S, Eliav E, Lavie D.; 2012. Coffee-based printing ink for food use.Abstract
A liq. coloring compn. comprises a coffee soln. or coffee ext. and an ink vehicle. The coloring compn. (composed of edible components) is suitable for use as an ink in a non-impact printing device, including an ink jet type printer. Thus, an ink formulation may include 89.9% coffee conc., 5% propylene glycol, 5% glycerol, and 0.1% Tween 80. A process for applying a design to a food substrate includes use of a non-impact printing device, in which the ink cartridge or external container contains this coloring compn. [on SciFinder(R)]
Magdassi S, Layani M.; 2012. Flexible transparent conductive coatings by direct room temperature evaporative lithography.Abstract
The invention provides a process for forming highly ordered, conductive and transparent patterns on flexible heat-sensitive surfaces. The invention relates to sintering nanoparticles at room temp. Patterning is done by a patterning device and the self-assembly of the nanoparticles. [on SciFinder(R)]
Meker S, Margulis-Goshen K, Weiss E, Magdassi S, Tshuva EY. Back Cover: High Antitumor Activity of Highly Resistant Salan-Titanium(IV) Complexes in Nanoparticles: An Identified Active Species (Angew. Chem. Int. Ed. 42/2012). Angewandte Chemie International Edition [Internet]. 2012;51 (42) :10672. Publisher's Version
Dvores MP, Marom G, Magdassi S. Formation of Organic Nanoparticlesby Electrospinningof Volatile Microemulsions. Langmuir [Internet]. 2012;28 (17) :6978 - 6984. Publisher's VersionAbstract
This study presents a method for one-step formation ofpoly(ethyleneoxide) nanofibers incorporating nanoparticles of a poorly water-solublecompound. Using the new method reported here, nanofiber–nanoparticlecomposites are fabricated in one step by electrospinning of an oil-in-watermicroemulsion, in which a model material, propylparaben, has beendissolved within the volatile dispersed phase in the presence of ahigh-molecular-weight polymer. The approach is based on nanoscaleconfinement to the dispersed phase of an oil-in-water microemulsionwith a volatile oil phase, in which the poorly water-soluble materialsare dissolved. Thus, when the thermodynamically stable oil-in-watermicroemulsion is combined with the rapid evaporation of solvent inherentin the electrospinning process, the droplets are converted into organicnanoparticles embedded within a polymeric nanofiber. In addition topossessing process simplicity, this method exhibits a very high percentageof nanoparticle loading with desirable active material properties.Specifically, the diameter of the nanofibers is in the range of 60–185nm, and propylparaben exists within the nanofiber as nanocrystalsof 30–120 nm. These dimensions suggest that the nanofiber–nanocrystalcomposites could serve as a delivery system for water-insoluble materials. [ABSTRACT FROM AUTHOR]Copyright of Langmuir is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Meker S, Margulis-Goshen K, Weiss E, Magdassi S, Tshuva EY. High antitumor activity of highly resistant salan-titanium(IV) complexes in nanoparticles: an identified active species. Angewandte Chemie (International Ed. In English)Angew Chem Int Ed Engl [Internet]. 2012;51 (42) :10515 - 10517. Publisher's VersionAbstract
A nanoformulated trinuclear hydrolysis product of a bis(alkoxo) salan-Ti(IV) complex shows high antitumor activity, which identifies it as an active species in cells. Additional highly stable mononuclear derivatives also show high activity, when formulated into nanoparticles, thus evincing that biologically friendly Ti(IV) can provide high cytotoxicity with controlled biological function.; Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Meker S, Margulis-Goshen K, Weiss E, Magdassi S, Tshuva EY. Rücktitelbild: High Antitumor Activity of Highly Resistant Salan-Titanium(IV) Complexes in Nanoparticles: An Identified Active Species (Angew. Chem. 42/2012). Angewandte Chemie [Internet]. 2012;124 (42) :10828. Publisher's Version
Margulis-Goshen K, Magdassi S. Organic nanoparticles from microemulsions: Formation and applications. [Internet]. 2012;(5) :290. Publisher's VersionAbstract
Microemulsions have already been recognized as convenient templates for nanoparticle synthesis. Spontaneous formation of the compartmentalized domains within the microemulsions leads to facile and low-cost preparation processes.
Layani M, Grouchko M, Shemesh S, Magdassi S. Conductive patterns on plastic substrates by sequential inkjet printing of silver nanoparticles and electrolyte sintering solutions. Journal of Materials Chemistry [Internet]. 2012;22 (29) :14349-14352. Publisher's Version
Grouchko M, Magdassi S, Azoubel S, Layani M, Kamyshny A. Copper ink-jet inks for flexible and plastic electronics. International Conference on Digital Printing Technologies [Internet]. 2012;(NIP 2012: 28th International Conference on Digital Printing Technologies and Digital Fabrication 2012 - Technical Program and Pr) :461-462. Publisher's Version
Suresh Kumar RS, Shiny PJ, Anjali CH, Jerobin J, Mukherjee A, Chandrasekaran N, Goshen KM, Magdassi S. Distinctive effects of nano-sized permethrin in the environmentDistinctive effects of nano-sized permethrin in the environment. Environmental Science and Pollution Research [Internet]. 2012 :1-10. Publisher's Version
Portnoy E, Gurina M, Magdassi S, Eyal S. Evaluation of the Near Infrared Compound Indocyanine Green as a Probe Substrate of P-Glycoprotein. [Internet]. 2012;9 (12) :3595 - 3601. Publisher's VersionAbstract

The efflux transporter P-glycoprotein (P-gp) affects the pharmacokinetics of many drugs. Currently used methods for characterization of P-gp's functional activity in vivo involve the use of radiolabeled substrates, are costly, and are technically demanding. Our objective was to evaluate whether the FDA-approved near-infrared compound indocyanine green (ICG) can be used as a probe substrate of P-gp. We also characterized the interaction of ICG with another efflux transporter, the breast cancer resistance protein (BCRP). We evaluated ICG accumulation and transport in MDCK cells overexpressing P-gp or BCRP (MDCK-MDRI and MDCK-BCRP, respectively) compared to control MDCK cells, in the presence or the absence of transporter inhibitors. In vivo imaging of ICG biodistribution in mice was conducted over 3.5 h using valspodar as the P-gp inhibitor. The EC50 values for ICG accumulation in control MDCK and MDCK-MDR1 cells were 9.0 x 10(-6) +/- 5.7 x 10(-7) M and 1.5 x 10(-5) +/- 1.1 x 10(-6) M, respectively. The efflux ratio for ICG in MDCK-MDR1 cells was 6.8-fold greater than in control cells. P-gp inhibition attenuated ICG efflux from MDR1-MDCK cells, and their effects in those cells were greater than in control MDCK cells. In contrast, BCRP level of expression or pharmacological inhibition did not significantly affect ICG cellular accumulation. In vivo imaging indicated enhanced cerebral ICG distribution with valspodar (brain - foot area under the concentration-time curves of 3.0 x 10(10), 5.6 x 10(10) and 3.7 x 10(19) h.[p/s/sr]/mu W in valspodar-treated mice vs 9.0 x 10(9) and 5.3 x 10(9) h.[p/s/sr]/mu W in controls). The findings from this pilot study suggest that near-infrared imaging using ICG as the probe substrate should be further characterized as a methodology for in vivo evaluation of P-gp activity.

Azoubel S, Shemesh S, Magdassi S. Flexible electroluminescent device with inkjet-printed carbon nanotube electrodes. [Internet]. 2012;23 (34). Publisher's VersionAbstract

Carbon nanotube (CNTs) inks may provide an effective route for producing flexible electronic devices by digital printing. In this paper we report on the formulation of highly concentrated aqueous CNT inks and demonstrate the fabrication of flexible electroluminescent (EL) devices by inkjet printing combined with wet coating. We also report, for the first time, on the formation of flexible EL devices in which all the electrodes are formed by inkjet printing of low-cost multi-walled carbon nanotubes (MWCNTs). Several flexible EL devices were fabricated by using different materials for the production of back and counter electrodes: ITO/MWCNT and MWCNT/MWCNT. Transparent electrodes were obtained either by coating a thin layer of the CNTs or by inkjet printing a grid which is composed of empty cells surrounded by MWCNTs. It was found that the conductivity and transparency of the electrodes are mainly controlled by the MWCNT film thickness, and that the dominant factor in the luminance intensity is the transparency of the electrode.

Dvores MP, Marom G, Magdassi S. Formation of Organic Nanoparticles by Electrospinning of Volatile Microemulsions. [Internet]. 2012;28 (17) :6978 - 6984. Publisher's VersionAbstract

This study presents a method for one-step formation of poly(ethylene oxide) nanofibers incorporating, nanoparticles of a poorly water-soluble compound. Using the new method reported here, nanofiber-nanoparticle composites are fabricated in one step by electrospinning of an oil-in-water microemulsion, in which a model material, propylparaben, has been dissolved within the volatile dispersed phase in the presence of a high-molecular-weight polymer. The approach is based on nanoscale confinement to the dispersed phase of an oil-in-water microemulsion with a volatile oil phase, in which the poorly water-soluble materials are dissolved. Thus, when the thermodynamically stable oil-in-water microemulsion is combined with the rapid evaporation of solvent inherent in the electrospinning process, the droplets are converted into organic nanoparticles embedded within a polymeric nanofiber. In addition to possessing process simplicity, this method exhibits a very high percentage of nanopartide loading with desirable active material properties. Specifically, the diameter of the nanofibers is in the range of 60-185 nm, and propylparaben exists within the nanofiber as nanocrystals of 30-120 nm. These dimensions suggest that the nanofiber nanocrystal composites could serve as a delivery system for water-insoluble materials.

Meker S, Weiss E, Tshuva EY, Margulis-Goshen K, Magdassi S. High antitumor activity of highly resistant salan-titanium(IV) complexes in nanoparticles: An identified active speciesHigh antitumor activity of highly resistant salan-titanium(IV) complexes in nanoparticles: An identified active species. Angewandte Chemie - International Edition [Internet]. 2012;51 (42) :10515-10517. Publisher's Version
Magdassi S, Azoubel S, Layani M, Grouchko M, Kamyshny A. Nanomaterials for printed electronicsNanomaterials for printed electronics, in International Conference on Digital Printing Technologies. ; 2012 :561-563. Publisher's Version
Frušić-Zlotkin M, Soroka Y, Verkhovsky L, Brégégère FM, Milner Y, Tivony R, Larush L, Magdassi S, Neuman R. Penetration and biological effects of topically applied cyclosporin A nanoparticles in a human skin organ culture inflammatory modelPenetration and biological effects of topically applied cyclosporin A nanoparticles in a human skin organ culture inflammat. Experimental Dermatology [Internet]. 2012;21 (12) :938-943. Publisher's Version

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