Publications/Patents

2014
Layani M, Darmawan P, Foo WL, Liu L, Kamyshny A, Mandler D, Magdassi S, Lee PS. Nanostructured electrochromic films by inkjet printing on large area and flexible transparent silver electrodes. NanoscaleNanoscale. 2014;6 (9) :4572 - 4576.Abstract
Printed electrochromic flexible films were obtained by combining transparent silver grid electrodes formed by self-assembly and inkjet printed WO3 nanoparticles. Concd. dispersions of WO3 nanoparticles were inkjet printed on transparent plastic silver grid electrodes with a high transparency of 83% in the spectral range of 400-800 nm, and a low sheet resistance in the range of 1-5 Ω sq-1. These electrodes were used for electrochromic applications for the first time. The resultant patterned nanostructured electrochromic films maintained their coloring and bleaching performance after bending of the flexible films. [on SciFinder(R)]
Eyal S, Magdassi S, Portnoy E, Zauberman J, Polyak B, Golenser J, Mardor Y, Ekstein D.; 2014. Compositions comprising near-infrared fluorescent particles and uses thereof for imaging activated immune cells in the CNS.Abstract
Pharmaceutical compn. comprising nanoparticles configured for enhanced phagocytosis by phagocytic cells and labeled with a near-IR (NIR) fluorescent probe bound to the outer surface thereof are provided, and uses thereof in the detection of activated immune cells in the central nervous system (CNS) of a subject. [on SciFinder(R)]
Magdassi S, Mandler D, Baidossi M, Larush L, Zwicker C, Nirenberg A, Binyamin Y.; 2014. High absorptivity, heat resistant coatings and related apparatus and methods.Abstract
A paint formulation can include an inorg. oxide-based pigment and an org. binder. The org. binder can be irreversibly converted to an inorg. binder upon curing of the paint formulation at a temp. greater than 200° C. The oxide-based pigment and/or the paint formulation itself can have an absorptivity of at least 80% with respect to the AM 1.5 spectrum. The paint formulation can also include at least one org. solvent, an inorg. filler, and/or at least one additive. Such paint formulations may be stable at high temps. (e.g., 750° C.) and can be used as solar-radiation-absorbing heat-resistant coatings for components of a solar tower system. [on SciFinder(R)]
Magdassi S, Mandler D, Baidossi M, Assa R, Chernin O, Binyamin Y.; 2014. Solar-radiation-absorbing formulations, application of paint, painted metal article and related apparatus.Abstract
Paint formulations having a high absorptivity with respect to solar radiation are described. The paint formulations are also thermally and mech. durable, enabling the paint formulations to be used on components in solar thermal applications where exposure to high temps. and environmental conditions may be an issue. The paint formulation can include an oxide-based pigment, an org. binder, ≥1 additives, an inorg. filler, and/or an org. solvent. The pigment can have a relatively high absorptivity with respect to light having a wavelength in the range 250-3000 nm. Curing of the paint formulation can irreversibly convert the org. binder into an inorg. binder. [on SciFinder(R)]
Magdassi S, Shapira A, Layani M, Cooperstein I.; 2014. Three-dimensional conductive patterns and inks for making same.Abstract
The invention generally relates to polymerizable conductive ink formulations comprising at least one metal source, at least one monomer and/or oligomer and a polymn. initiator, and uses thereof for printing three-dimensional functional structures. In particular a method of fabricating a three-dimensional conductive pattern on a substrate is disclosed, the method comprising: (a) forming a pattern on a surface region of a substrate by using an ink comprising at least one metal source, at least one liq. polymerizable monomer and/or oligomer, and at least one polymn. initiator; (b) polymg. at least a portion of said liq. monomer and/or oligomer; (c) rendering the metal source a continuous percolation path for elec. cond. (sintering); (d) repeating steps (a), (b) and optionally (c) to obtain a three-dimensional conductive pattern. [on SciFinder(R)]
Gordon V, Marom G, Magdassi S. Formation of hydrophilic nanofibers from nanoemulsions through electrospinning. International Journal Of PharmaceuticsInt J Pharm [Internet]. 2014;478 (1) :172 - 179. Publisher's VersionAbstract
This study presents a method for one step incorporation of lipophilic compounds in hydrophilic nanofibers. By this method nanodroplets of oil and of volatile solvent are entrapped within polymer nanofibers during an electrospinning process. While performing the process with a volatile oil with dissolved lipophilic material, such as the drug celecoxib, nanofiber-nanoparticle composites are formed. The polymer used to form the fibers is a high molecular weight poly(vinyl alcohol) which enables rapid dissolution and release of the incorporated lipophilic material. The resulting celecoxib nanoparticles that are embedded within the nanofiber are amorphous and their average size is in between 21 and 93nm, thus potentially lead to their increased dissolution rate. The preparation of such a solid matrix containing nanodroplets or nanoparticles may be applied as a fast dissolving delivery system for water insoluble materials.; Copyright © 2014 Elsevier B.V. All rights reserved.
Leonard F, Margulis-Goshen K, Liu X, Srinivasan S, Magdassi S, Godin B. Low pressure mediated enhancement of nanoparticle and macromolecule loading into porous silicon structures. Mesoporous BiomaterialsMesoporous Biomater [Internet]. 2014;1 (1). Publisher's VersionAbstract
Ensuring drug loading efficiency and consistency is one of the most critical stages in engineering drug delivery vectors based on porous materials. Here we propose a technique to significantly enhance the efficiency of loading by employing simple and widely available methods: applying low pressure with and without centrifugation. Our results point toward the advantages the proposed method over the passive loading, especially where the size difference of loaded materials and the pore size of the porous silicon particles is smaller, an increase up to 20-fold can be observed. The technique described in the study can be used for efficient and reproducible loading of porous materials with therapeutic molecules, nanoparticles and contrast imaging agents for biomedical application.;
Cao X, Wang N, Law JY, Joachim Loo SC, Magdassi S, Long Y. Nanoporous Thermochromic VO2(M) Thin Films:Controlled Porosity, Largely Enhanced Luminous Transmittance and Solar Modulating Ability. Langmuir [Internet]. 2014;30 (6) :1710 - 1715. Publisher's VersionAbstract
Vanadiumdioxide is the most widely researched thermochromic materialwith a phase transition temperature (τc) of around68 °C, and its thermochromic performance can be enhanced by addingnanoporosity. Freeze-drying has been employed to fabricate nanostructureswith different porosities from 16 to 45% by varying the prefreezingtemperature and precursor concentration. The luminous transmittance(Tlum) and solar modulating ability (ΔTsol) are greatly enhanced as a result of increasingpore size and pore density. The freeze-dried sample with 7.5 mL ofH2O2precursor dip-coated at 300 mm/min givesthe best combination of thermochromic properties (Tlum≈ 50%, ΔTsol= 14.7%), which surpasses the best combined thermochromic performancereported to date that we are aware of (Tlum≈ 41%, ΔTsol= 14.1%). [ABSTRACT FROM AUTHOR]Copyright of Langmuir is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Magdassi S, Margulis K, Srinivasan S, Godin B, Ware MJ, Summers HD. Active curcumin nanoparticles formed from a volatile Microemulsion template. Journal of Materials Chemistry B [Internet]. 2014;2 (24) :3745. Publisher's VersionAbstract
We report on the biological performance of organic nanoparticles formed by a simple method based on rapid solvent removal from a volatile microemulsion. The particular focus of the study was on testing the suitability of the method for substances soluble in partially water-miscible organic solvents as well as on evaluating the therapeutic activity of the resultant nanoparticles. Curcumin was employed as a model for hydrophobic drugs, and, as it is soluble in water-miscible organic solvents, it was successfully incorporated into a new cyclopentanone-water microemulsion system. During rapid solvent removal by spray-drying, the nanometric droplets of the microemulsion were converted into nanoparticles containing amorphous curcumin with an average size of 20.2 ± 3.4 nm, having a ς potential of -36.2 ± 1.8 mV. These nanoparticles were dispersible in water and retained the high loading of the active substance. The therapeutic activity of the resulting nanoparticles was demonstrated in a pancreatic cancer cell line, PANC-1. The effective concentration for reducing the metabolic activity by 50% (EC50) was found to be 11.5 µM for nanoparticles compared with 19.5 µM for free curcumin. [ABSTRACT FROM AUTHOR]Copyright of Journal of Materials Chemistry B is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Margulis K, Srinivasan S, Ware MJ, Summers HD, Godin B, Magdassi S. Active curcumin nanoparticles formed from a volatile microemulsion template. Journal of Materials Chemistry B [Internet]. 2014;2 (26) :3745. Publisher's VersionAbstract
We report on the biological performance of organic nanoparticles formed by a simple method based on rapid solvent removal from a volatile microemulsion. The particular focus of the study was on testing the suitability of the method for substances soluble in partially water-miscible organic solvents as well as on evaluating the therapeutic activity of the resultant nanoparticles. Curcumin was employed as a model for hydrophobic drugs, and, as it is soluble in water-miscible organic solvents, it was successfully incorporated into a new cyclopentanone-water microemulsion system. During rapid solvent removal by spray-drying, the nanometric droplets of the microemulsion were converted into nanoparticles containing amorphous curcumin with an average size of 20.2 ± 3.4 nm, having a ζ potential of -36.2 ± 1.8 mV. These nanoparticles were dispersible in water and retained the high loading of the active substance. The therapeutic activity of the resulting nanoparticles was demonstrated in a pancreatic cancer cell line, PANC-1. The effective concentration for reducing the metabolic activity by 50% (EC50) was found to be 11.5 mM for nanoparticles compared with 19.5 µM for free curcumin. [ABSTRACT FROM AUTHOR]Copyright of Journal of Materials Chemistry B is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Lim HM, Tan JY, Batabyal SK, Magdassi S, Mhaisalkar SG, Wong LH. Inside Back Cover: Photoactive Nanocrystals by Low-Temperature Welding of Copper Sulfide Nanoparticles and Indium Sulfide Nanosheets (ChemSusChem 12/2014). ChemSusChem [Internet]. 2014;7 (12) :3549. Publisher's VersionAbstract
The cover page of the December 2014 issue of the journal "Chemistry and Sustainability" is presented.
Gabizon R, Mizrahi M, Friedman-Levy Y, Larush L, Frid K, Binyamin O, Dori D, Feinstein N, Ovadia H, Ben-Hur T, et al. P.221: Novel pomegranate oil nano-emulsions for the prevention and treatment of neurodegenerative diseases: The case of genetic CJD. Prion [Internet]. 2014;8 :131. Publisher's Version
Liu L, Layani M, Yellinek S, Kamyshny A, Ling H, Lee PS, Magdassi S, Mandler D. "Nano to nano" electrodeposition of WO3 crystalline nanoparticles for electrochromic coatings†. Journal of Materials Chemistry A [Internet]. 2014;2 (38) :16224. Publisher's VersionAbstract
A "nano to nano" electrodeposition approach for preparing nano-structured thin films from the dispersion of nano-objects is reported. A typical WO3 system is demonstrated, where nanocrystalline films are electrodeposited onto transparent conductive electrodes such as ITO and Ag grid printed PET (Ag grid/PET) from the water dispersion of WO3 nanoparticles without applying high potential, adding surfactants or polymers. The process is based on the reduction of WO3, which eliminates the electrostatic repulsion between the nanoparticles causing film deposition on the cathode. The reduced WO3 (HWO3) is conductive, thus it allows further film growth towards higher thickness and coverage. The electrodeposited films consist of stacked crystalline nanoparticles, which provide a highly active surface area, facilitate the penetration of electrolyte and the intercalation/deintercalation of Li+ in the nanocrystals and therefore result in outstanding electrochromic performance and stability (92% contrast, 9 s coloring and 15 s bleaching, retaining 76% contrast after 1000 coloring-bleaching cycles). The thickness, electrochromic performance and surface coverage of the films are well tuned by potential and time. This novel "nano to nano" electrodeposition approach based on the electrochemical redox of nano-objects can be extended to various transition metal oxide nano-objects with different sizes and shapes. [ABSTRACT FROM AUTHOR]Copyright of Journal of Materials Chemistry A is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Tulchinsky D, Uvarov V, Popov I, Mandler D, Magdassi S. A novel non-selective coating material for solar thermal potential application formed by reaction between sol–gel titania and copper manganese spinel. Solar Energy Materials and Solar Cells [Internet]. 2014;120 (Part A) :23 - 29. Publisher's VersionAbstract
A method for preparing a novel bixbyite non-selective coating for solar thermal conversion is described. The coating is formed by a thermal reaction between a titania sol–gel precursor with a copper manganese spinel to form a new material, Cu0.44Ti0.44Mn0.84Fe0.28O3, with a bixbyite structure. The effect of temperature and ratio between the two components on the formation of the bixbyite layer (deposited on Inconel by spray-coating) was studied. The absorptance of the films (AM 1.5; 335–2500nm) with a thickness of 10±2µm after annealing at 2h at 650°C and 750°C was 97.4% and 94.7%, respectively. This synthesis represents a novel approach in which the final solar thermal coating is formed as a continuous and uniform layer which combines both the absorber and the ceramic binder. The developed material shows promising results for future applications as absorber in solar thermal energy conversion.•A new material combining the absorber and a ceramic matrix was formed.•This material was used for solar thermal application with high absorptivity.•The formation of the material occurred by thermal treatment of a sprayed thin film.
Wünscher S, Rasp T, Grouchko M, Kamyshny A, Paulus RM, Perelaer J, Kraft T, Magdassi S, Schubert US. Simulation and prediction of the thermal sintering behavior for a silver nanoparticle ink based on experimental input. Journal of Materials Chemistry C [Internet]. 2014;2 (31) :6342. Publisher's VersionAbstract
In order to develop a prediction model for resistivity evolution during isothermal sintering, a commercial silver nanoparticle ink was characterized for its metal content, particle size and behavior upon heating. Electrical properties, mass loss behavior, grain size development and material densification were studied for thermal sintering at 175 °C. The correlation between mass loss, height loss of the resulting sintered structures, grain size and electrical resistivity was investigated to gain further understanding of the silver nanoparticle sintering process. The results of thermal sintering were used to calibrate a discrete element sintering model that provides microstructural properties with which the resistivity development at 150 and 200 °C was successfully predicted. The model was validated by experimental data obtained at these temperatures. A variation of particle size and particle size distribution in the simulations furthermore illustrate their influence on final resistivity showing that using small particles with a broad distribution are preferable for reducing the final resistivity of the inkjet-printed pattern. [ABSTRACT FROM AUTHOR]Copyright of Journal of Materials Chemistry C is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Meker S, Margulis-Goshen K, Weiss E, Braitbard O, Hochman J, Magdassi S, Tshuva EY. Anti-proliferative Activity of Nano-Formulated Phenolato Titanium(IV) Complexes Against Cancer Cells. [Internet]. 2014;(6) :1294. Publisher's Version
Lu Z, Layani M, Zhao X, Tan LP, Sun T, Fan S, Yan Q, Magdassi S, Hng HH. Fabrication of Flexible Thermoelectric Thin Film Devices by Inkjet Printing. [Internet]. 2014;(17) :3551. Publisher's Version
Margulis K, Magdassi S, Lee HS, Macosko CW. Formation of curcumin nanoparticles by flash nanoprecipitation from emulsions. Journal of Colloid And Interface Science [Internet]. 2014;434 :65 - 70. Publisher's VersionAbstract
•A new method for production of organic nanoparticles is demonstrated for curcumin.•The method is based on flash nanoprecipitation from partially water-soluble emulsions.•A simple hand-operated mixer is employed for flash nanoprecipitation process.•Dry nanometric powders obtained by spray drying are easily dispersible in water.•The resultant particles are 40nm in diameter and contain above 20wt% active substance.Nanometric particles of a model hydrophobic substance curcumin were prepared by a novel method, namely, flash nanoprecipitation from a coarse oil-in-water emulsion. The method employs turbulent co-mixing of water with curcumin-loaded emulsion using manually-operated confined impingement jets mixer. A clear and stable dispersion of nanoparticles was formed in this process, and could be converted to dry, easily water-dispersible powder by spray drying. The mean size of the particles was about 40nm by DLS, confirmed by Cryo-TEM. The obtained particles contained 20.4wt% curcumin, X-ray analysis showed it was amorphous. The significant advantages of the studied process are its feasibility, speed and low cost. It does not require any special high-energy input equipment to reduce the droplet size of the initial emulsion as required by the vast majority of other methods, and relies on rapid turbulent mixing and on flow-induced shear stress formed in the simple, manually-operated mixer. Control experiments clearly indicate that employing emulsion, instead of a plain solution and flash nanoprecipitation instead of a simple antisolvent precipitation are advantageous in terms of particle size and stability.
Lim HM, Tan JY, Batabyal SK, Magdassi S, Mhaisalkar SG, Wong LH. Photoactive Nanocrystals by Low-Temperature Welding of Copper Sulfide Nanoparticles and Indium Sulfide Nanosheets. [Internet]. 2014;(12) :3290. Publisher's Version
Katzir E, Yochelis S, Paltiel Y, Azoubel S, Shimoni A, Magdassi S. Review: Tunable inkjet printed hybrid carbon nanotubes/nanocrystals light sensor. Sensors & Actuators: B. Chemical [Internet]. 2014;196 :112 - 116. Publisher's VersionAbstract
In recent years carbon based devices are exploited for a wide range of applications related to electronics and optoelectronics, due to their unique electrical, optical and mechanical properties. Many sensors, emitters, transistors and logic devices use carbon nanotubes as their major building block. Here we present a technology for inkjet printing of a hybrid tunable detector composed of carbon nanotubes and nanocrystals. The printing can be performed on flexible elastic transparent substrates, as well as on a rigid semiconductor or dielectric substrates. The presented detector is low cost, operates at room temperature and can be printed easily in a large format. We show that these types of sensor function with high quantum efficiency due to a gating effect induced by the light excitation.

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