Publications/Patents

2015
Cooperstein I, Layani M, Magdassi S. 3D printing of porous structures by UV-curable O/W emulsion for fabrication of conductive objects. Journal of Materials Chemistry C. 2015;3 (9) :2040.Abstract

The growing interest in the field of three-dimensional printing has led to great demand for new materials. In this paper we should like to present a new ink for printing porous structures that can be used for embedding various functional materials. The ink is composed of a UV polymerizable oil-in-water emulsion which converts into a solid object upon UV irradiation, and upon evaporation of the aqueous phase, forms a porous structure. The 3D objects with their various porosities, were printed by a Digital Light Processing (DLP) printer. The total surface area of the object can be controlled by changing the emulsion's droplets size and the dispersed phase fraction. The printed 3D porous structures can be used in a variety of applications, and here we show a composite conductive object, made of silver and cross-linked polymer. After the porous object is formed, the pores are filled by vacuum, dipping in a dispersion of silver nanoparticles, followed by chemical sintering at room temperature, which results in conductive percolation paths within the 3D structure. Application of this structure is demonstrated for use as a 3D connector of an electrical circuit. [ABSTRACT FROM AUTHOR]Copyright of Journal of Materials Chemistry C is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Gordon V, Marom G, Magdassi S. Formation of hydrophilic nanofibers from nanoemulsions through electrospinningFormation of hydrophilic nanofibers from nanoemulsions through electrospinning. International Journal of Pharmaceutics [Internet]. 2015;478 (1) :172-179. Publisher's Version
Portnoy E, Nizri E, Golenser J, Shmuel M, Magdassi S, Eyal S. Imaging the urinary pathways in mice by liposomal indocyanine green. Nanomedicine: Nanotechnology, Biology, and Medicine [Internet]. 2015;11 :1057 - 1064. Publisher's VersionAbstract

Intraoperative ureter identification can assist in the prevention of ureteral injury and consequently improve surgery outcomes. Our aim was to take advantage of the altered pharmacokinetics of liposomal indocyanine green (ICG), the only FDA-approved near-infrared (NIR) dye, for imaging of ureters during surgeries. ICG was passively adsorbed to liposomes. NIR whole mice body and isolated tissue imaging were used to study liposomal ICG properties vs. free ICG. In vivo, the urinary bladder could be clearly observed in most of the liposome-treated mice. Liposomal encapsulation of ICG enhanced ureteral emission up to 1.9 fold compared to free ICG (P<0.01). Increase in liposomal micropolarity and microviscosity and differential scanning calorimetry supported ICG localization within the liposomal bilayer. Our findings suggest that liposomal ICG could be utilized for ureteral imaging intra-operatively, thus potentially improving surgical outcomes.

Rosen Y, Grouchko M, Magdassi S. Printed Electronics: Printing a Self-Reducing Copper Precursor on 2D and 3D Objects to Yield Copper Patterns with 50% Copper's Bulk Conductivity. Advanced Materials Interfaces. 2015;2 (3) :1400448.Abstract

The patterning of various 2D and 3D substrates is accomplished using a new method, reactive transfer printing, combined with a self-reducing copper precursor. The ink composed of the metal precursor is printed on a donor substrate; during its decomposition, the metal is transferred to an acceptor substrate. This process is demonstrated with copper formate as the precursor, forming a copper pattern with excellent conductivity (50% that of bulk copper).

Farraj Y, Grouchko M, Magdassi S. Self-reduction of a copper complex MOD ink for inkjet printing conductive patterns on plasticsSelf-reduction of a copper complex MOD ink for inkjet printing conductive patterns on plastics. Chemical Communications. 2015;51 (9) :1587-1590.Abstract

Highly conductive copper patterns on low-cost flexible substrates are obtained by inkjet printing a metal complex based ink. Upon heating the ink, the soluble complex, which is composed of copper formate and 2-amino-2-methyl-1-propanol, decomposes under nitrogen at 140 °C and is converted to pure metallic copper. The decomposition process of the complex is investigated and a suggested mechanism is presented. The ink is stable in air for prolonged periods, with no sedimentation or oxidation problems, which are usually encountered in copper nanoparticle based inks.

 

Liu C, Long Y, Balin I, Abdulhalim I, Magdassi S. Vanadium dioxide nanogrid films for high transparency smart architectural window applicationsVanadium dioxide nanogrid films for high transparency smart architectural window applications. Optics Express [Internet]. 2015;23 (3) :A124-A132. Publisher's Version
2014
Layani M, Kamyshny A, Magdassi S. Transparent conductors composed of nanomaterials. NanoscaleNanoscale. 2014;6 (11) :5581 - 5591.Abstract
This is a review on recent developments in the field of transparent conductive coatings (TCCs) for ITO replacement. The review describes the basic properties of conductive nanomaterials suitable for fabrication of such TCCs (metallic nanoparticles and nanowires, carbon nanotubes and graphene sheets), various methods of patterning the metal nanoparticles with formation of conductive transparent metallic grids, honeycomb structures and 2D arrays of interconnected rings as well as fabrication of TCCs based on graphene and carbon nanotubes. Applications of TCCs in electronic and optoelectronic devices, such as solar cells, electroluminescent and electrochromic devices, touch screens and displays, and transparent EMI shielders, are discussed. [on SciFinder(R)]
Layani M, Darmawan P, Foo WL, Liu L, Kamyshny A, Mandler D, Magdassi S, Lee PS. Nanostructured electrochromic films by inkjet printing on large area and flexible transparent silver electrodes. NanoscaleNanoscale. 2014;6 (9) :4572 - 4576.Abstract
Printed electrochromic flexible films were obtained by combining transparent silver grid electrodes formed by self-assembly and inkjet printed WO3 nanoparticles. Concd. dispersions of WO3 nanoparticles were inkjet printed on transparent plastic silver grid electrodes with a high transparency of 83% in the spectral range of 400-800 nm, and a low sheet resistance in the range of 1-5 Ω sq-1. These electrodes were used for electrochromic applications for the first time. The resultant patterned nanostructured electrochromic films maintained their coloring and bleaching performance after bending of the flexible films. [on SciFinder(R)]
Eyal S, Magdassi S, Portnoy E, Zauberman J, Polyak B, Golenser J, Mardor Y, Ekstein D.; 2014. Compositions comprising near-infrared fluorescent particles and uses thereof for imaging activated immune cells in the CNS.Abstract
Pharmaceutical compn. comprising nanoparticles configured for enhanced phagocytosis by phagocytic cells and labeled with a near-IR (NIR) fluorescent probe bound to the outer surface thereof are provided, and uses thereof in the detection of activated immune cells in the central nervous system (CNS) of a subject. [on SciFinder(R)]
Magdassi S, Mandler D, Baidossi M, Larush L, Zwicker C, Nirenberg A, Binyamin Y.; 2014. High absorptivity, heat resistant coatings and related apparatus and methods.Abstract
A paint formulation can include an inorg. oxide-based pigment and an org. binder. The org. binder can be irreversibly converted to an inorg. binder upon curing of the paint formulation at a temp. greater than 200° C. The oxide-based pigment and/or the paint formulation itself can have an absorptivity of at least 80% with respect to the AM 1.5 spectrum. The paint formulation can also include at least one org. solvent, an inorg. filler, and/or at least one additive. Such paint formulations may be stable at high temps. (e.g., 750° C.) and can be used as solar-radiation-absorbing heat-resistant coatings for components of a solar tower system. [on SciFinder(R)]
Magdassi S, Mandler D, Baidossi M, Assa R, Chernin O, Binyamin Y.; 2014. Solar-radiation-absorbing formulations, application of paint, painted metal article and related apparatus.Abstract
Paint formulations having a high absorptivity with respect to solar radiation are described. The paint formulations are also thermally and mech. durable, enabling the paint formulations to be used on components in solar thermal applications where exposure to high temps. and environmental conditions may be an issue. The paint formulation can include an oxide-based pigment, an org. binder, ≥1 additives, an inorg. filler, and/or an org. solvent. The pigment can have a relatively high absorptivity with respect to light having a wavelength in the range 250-3000 nm. Curing of the paint formulation can irreversibly convert the org. binder into an inorg. binder. [on SciFinder(R)]
Magdassi S, Shapira A, Layani M, Cooperstein I.; 2014. Three-dimensional conductive patterns and inks for making same.Abstract
The invention generally relates to polymerizable conductive ink formulations comprising at least one metal source, at least one monomer and/or oligomer and a polymn. initiator, and uses thereof for printing three-dimensional functional structures. In particular a method of fabricating a three-dimensional conductive pattern on a substrate is disclosed, the method comprising: (a) forming a pattern on a surface region of a substrate by using an ink comprising at least one metal source, at least one liq. polymerizable monomer and/or oligomer, and at least one polymn. initiator; (b) polymg. at least a portion of said liq. monomer and/or oligomer; (c) rendering the metal source a continuous percolation path for elec. cond. (sintering); (d) repeating steps (a), (b) and optionally (c) to obtain a three-dimensional conductive pattern. [on SciFinder(R)]
Gordon V, Marom G, Magdassi S. Formation of hydrophilic nanofibers from nanoemulsions through electrospinning. International Journal Of PharmaceuticsInt J Pharm [Internet]. 2014;478 (1) :172 - 179. Publisher's VersionAbstract
This study presents a method for one step incorporation of lipophilic compounds in hydrophilic nanofibers. By this method nanodroplets of oil and of volatile solvent are entrapped within polymer nanofibers during an electrospinning process. While performing the process with a volatile oil with dissolved lipophilic material, such as the drug celecoxib, nanofiber-nanoparticle composites are formed. The polymer used to form the fibers is a high molecular weight poly(vinyl alcohol) which enables rapid dissolution and release of the incorporated lipophilic material. The resulting celecoxib nanoparticles that are embedded within the nanofiber are amorphous and their average size is in between 21 and 93nm, thus potentially lead to their increased dissolution rate. The preparation of such a solid matrix containing nanodroplets or nanoparticles may be applied as a fast dissolving delivery system for water insoluble materials.; Copyright © 2014 Elsevier B.V. All rights reserved.
Leonard F, Margulis-Goshen K, Liu X, Srinivasan S, Magdassi S, Godin B. Low pressure mediated enhancement of nanoparticle and macromolecule loading into porous silicon structures. Mesoporous BiomaterialsMesoporous Biomater [Internet]. 2014;1 (1). Publisher's VersionAbstract
Ensuring drug loading efficiency and consistency is one of the most critical stages in engineering drug delivery vectors based on porous materials. Here we propose a technique to significantly enhance the efficiency of loading by employing simple and widely available methods: applying low pressure with and without centrifugation. Our results point toward the advantages the proposed method over the passive loading, especially where the size difference of loaded materials and the pore size of the porous silicon particles is smaller, an increase up to 20-fold can be observed. The technique described in the study can be used for efficient and reproducible loading of porous materials with therapeutic molecules, nanoparticles and contrast imaging agents for biomedical application.;
Cao X, Wang N, Law JY, Joachim Loo SC, Magdassi S, Long Y. Nanoporous Thermochromic VO2(M) Thin Films:Controlled Porosity, Largely Enhanced Luminous Transmittance and Solar Modulating Ability. Langmuir [Internet]. 2014;30 (6) :1710 - 1715. Publisher's VersionAbstract
Vanadiumdioxide is the most widely researched thermochromic materialwith a phase transition temperature (τc) of around68 °C, and its thermochromic performance can be enhanced by addingnanoporosity. Freeze-drying has been employed to fabricate nanostructureswith different porosities from 16 to 45% by varying the prefreezingtemperature and precursor concentration. The luminous transmittance(Tlum) and solar modulating ability (ΔTsol) are greatly enhanced as a result of increasingpore size and pore density. The freeze-dried sample with 7.5 mL ofH2O2precursor dip-coated at 300 mm/min givesthe best combination of thermochromic properties (Tlum≈ 50%, ΔTsol= 14.7%), which surpasses the best combined thermochromic performancereported to date that we are aware of (Tlum≈ 41%, ΔTsol= 14.1%). [ABSTRACT FROM AUTHOR]Copyright of Langmuir is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Margulis K, Srinivasan S, Ware MJ, Summers HD, Godin B, Magdassi S. Active curcumin nanoparticles formed from a volatile microemulsion template. Journal of Materials Chemistry B [Internet]. 2014;2 (26) :3745. Publisher's VersionAbstract
We report on the biological performance of organic nanoparticles formed by a simple method based on rapid solvent removal from a volatile microemulsion. The particular focus of the study was on testing the suitability of the method for substances soluble in partially water-miscible organic solvents as well as on evaluating the therapeutic activity of the resultant nanoparticles. Curcumin was employed as a model for hydrophobic drugs, and, as it is soluble in water-miscible organic solvents, it was successfully incorporated into a new cyclopentanone-water microemulsion system. During rapid solvent removal by spray-drying, the nanometric droplets of the microemulsion were converted into nanoparticles containing amorphous curcumin with an average size of 20.2 ± 3.4 nm, having a ζ potential of -36.2 ± 1.8 mV. These nanoparticles were dispersible in water and retained the high loading of the active substance. The therapeutic activity of the resulting nanoparticles was demonstrated in a pancreatic cancer cell line, PANC-1. The effective concentration for reducing the metabolic activity by 50% (EC50) was found to be 11.5 mM for nanoparticles compared with 19.5 µM for free curcumin. [ABSTRACT FROM AUTHOR]Copyright of Journal of Materials Chemistry B is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Magdassi S, Margulis K, Srinivasan S, Godin B, Ware MJ, Summers HD. Active curcumin nanoparticles formed from a volatile Microemulsion template. Journal of Materials Chemistry B [Internet]. 2014;2 (24) :3745. Publisher's VersionAbstract
We report on the biological performance of organic nanoparticles formed by a simple method based on rapid solvent removal from a volatile microemulsion. The particular focus of the study was on testing the suitability of the method for substances soluble in partially water-miscible organic solvents as well as on evaluating the therapeutic activity of the resultant nanoparticles. Curcumin was employed as a model for hydrophobic drugs, and, as it is soluble in water-miscible organic solvents, it was successfully incorporated into a new cyclopentanone-water microemulsion system. During rapid solvent removal by spray-drying, the nanometric droplets of the microemulsion were converted into nanoparticles containing amorphous curcumin with an average size of 20.2 ± 3.4 nm, having a ς potential of -36.2 ± 1.8 mV. These nanoparticles were dispersible in water and retained the high loading of the active substance. The therapeutic activity of the resulting nanoparticles was demonstrated in a pancreatic cancer cell line, PANC-1. The effective concentration for reducing the metabolic activity by 50% (EC50) was found to be 11.5 µM for nanoparticles compared with 19.5 µM for free curcumin. [ABSTRACT FROM AUTHOR]Copyright of Journal of Materials Chemistry B is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Lim HM, Tan JY, Batabyal SK, Magdassi S, Mhaisalkar SG, Wong LH. Inside Back Cover: Photoactive Nanocrystals by Low-Temperature Welding of Copper Sulfide Nanoparticles and Indium Sulfide Nanosheets (ChemSusChem 12/2014). ChemSusChem [Internet]. 2014;7 (12) :3549. Publisher's VersionAbstract
The cover page of the December 2014 issue of the journal "Chemistry and Sustainability" is presented.
Gabizon R, Mizrahi M, Friedman-Levy Y, Larush L, Frid K, Binyamin O, Dori D, Feinstein N, Ovadia H, Ben-Hur T, et al. P.221: Novel pomegranate oil nano-emulsions for the prevention and treatment of neurodegenerative diseases: The case of genetic CJD. Prion [Internet]. 2014;8 :131. Publisher's Version
Liu L, Layani M, Yellinek S, Kamyshny A, Ling H, Lee PS, Magdassi S, Mandler D. "Nano to nano" electrodeposition of WO3 crystalline nanoparticles for electrochromic coatings†. Journal of Materials Chemistry A [Internet]. 2014;2 (38) :16224. Publisher's VersionAbstract
A "nano to nano" electrodeposition approach for preparing nano-structured thin films from the dispersion of nano-objects is reported. A typical WO3 system is demonstrated, where nanocrystalline films are electrodeposited onto transparent conductive electrodes such as ITO and Ag grid printed PET (Ag grid/PET) from the water dispersion of WO3 nanoparticles without applying high potential, adding surfactants or polymers. The process is based on the reduction of WO3, which eliminates the electrostatic repulsion between the nanoparticles causing film deposition on the cathode. The reduced WO3 (HWO3) is conductive, thus it allows further film growth towards higher thickness and coverage. The electrodeposited films consist of stacked crystalline nanoparticles, which provide a highly active surface area, facilitate the penetration of electrolyte and the intercalation/deintercalation of Li+ in the nanocrystals and therefore result in outstanding electrochromic performance and stability (92% contrast, 9 s coloring and 15 s bleaching, retaining 76% contrast after 1000 coloring-bleaching cycles). The thickness, electrochromic performance and surface coverage of the films are well tuned by potential and time. This novel "nano to nano" electrodeposition approach based on the electrochemical redox of nano-objects can be extended to various transition metal oxide nano-objects with different sizes and shapes. [ABSTRACT FROM AUTHOR]Copyright of Journal of Materials Chemistry A is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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