@article {7483,
	title = {Merging Allylic Carbon-Hydrogen and Selective Carbon-Carbon bond Activation},
	journal = {Nature},
	volume = {505},
	year = {2014},
	pages = {199{\textendash}203},
	abstract = {
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Merging allylic carbon{\textendash}hydrogen and selective carbon{\textendash}carbon bond activation

Ahmad Masarwa,
Dorian Didier,
Tamar Zabrodski,
Marvin Schinkel,
Lutz Ackermann
\&amp; Ilan Marek


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Nature505,199{\textendash}203(09 January 2014)doi:10.1038/nature12761Received22 August 2013Accepted08 October 2013Published online08 December 2013

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Since the nineteenth century, many synthetic organic chemists have focused on developing new strategies to regio-, diastereo- and enantioselectively build carbon{\textendash}carbon and carbon{\textendash}heteroatom bonds in a predictable and efficient manner1, 2, 3. Ideal syntheses should use the least number of synthetic steps, with few or no functional group transformations and by-products, and maximum atom efficiency. One potentially attractive method for the synthesis of molecular skeletons that are difficult to prepare would be through the selective activation of C{\textendash}H and C{\textendash}C bonds4, 5, 6, 7, 8, instead of the conventional construction of new C{\textendash}C bonds. Here we present an approach that exploits the multifold reactivity of easily accessible substrates9 with a single organometallic species to furnish complex molecular scaffolds through the merging of otherwise difficult transformations: allylic C{\textendash}H and selective C{\textendash}C bond activations10, 11, 12. The resulting bifunctional nucleophilic species, all of which have an all-carbon quaternary stereogenic centre, can then be selectively derivatized by the addition of two different electrophiles to obtain more complex molecular architecture from these easily available starting materials.
},
	url = {http://www.nature.com/nature/journal/v505/n7482/full/nature12761.html},
	author = {Ahmad Masarwa and Dorian Didier and Tamar Zabrodski and Marvin Schinkel and Lutz Ackermann and Ilan Marek*}
}
