Last updated on 11/19/2021
I. Alshanski, M. Bentolila, A. Gitlin-Domagalska, D. Zamir, S. Zorsky, S. Joubran, M. Hurevich, and C. Gilon. 2018. “Enhancing the Efficiency of the Solid Phase Peptide Synthesis (SPPS) Process by High Shear Mixing.” Organic Process Research & Development, 22, 9, Pp. 1318-1322. ://WOS:000445711200030'>Publisher's Version
The brittle nature of the polymer beads used in SPPS dictates mild mixing techniques with low mass transfer. We demonstrate that vigorous overhead mechanical stirring with superior mass transfer properties kept the beads intact and significantly accelerates reaction kinetics and efficiency.