@article {RN17,
	title = {Automated assembly of oligosaccharides containing multiple cis-glycosidic linkages},
	journal = {Nature Communications},
	volume = {7},
	year = {2016},
	type = {Journal Article},
	abstract = {Automated glycan assembly (AGA) has advanced from a concept to a commercial technology that rapidly provides access to diverse oligosaccharide chains as long as 30-mers. To date, AGA was mainly employed to incorporate\&nbsp;trans-glycosidic linkages, where C2 participating protecting groups ensure stereoselective couplings. Stereocontrol during the installation of\&nbsp;cis-glycosidic linkages cannot rely on C2-participation and anomeric mixtures are typically formed. Here, we demonstrate that oligosaccharides containing multiple\&nbsp;cis-glycosidic linkages can be prepared efficiently by AGA using monosaccharide building blocks equipped with remote participating protecting groups. The concept is illustrated by the automated syntheses of biologically relevant oligosaccharides bearing various\&nbsp;cis-galactosidic and\&nbsp;cis-glucosidic linkages. This work provides further proof that AGA facilitates the synthesis of complex oligosaccharides with multiple\&nbsp;cis-linkages and other biologically important oligosaccharides.[[{"fid":"26192","view_mode":"default","type":"media","attributes":{"height":"301.9965515136719","width":"822.9861450195312","alt":"Nat Comm 2016 TOC","class":"media-element file-default"}}]]},
	issn = {2041-1723},
	doi = {ARTN 12482 10.1038/ncomms12482},
	author = {Hahm, H. S. and Hurevich, M. and Seeberger, P. H.}
}
