K., Jospe, Genzer S., Selle klein N., Ong D., Zaki J., and Perry A.The contribution of linguistic and visual cues to physiological synchrony and empathic accuracy.” Cortex 132 (2020): 296-208. Publisher's VersionAbstract

There is an ongoing debate concerning the contribution of different aspects of empathy to achieving an accurate understanding of others. In this study, we aimed to better comprehend the roles of experience sharing and mentalizing using a modified empathic-accuracy task. We analyzed the unique contribution of each of these mechanisms with an explicit cognitive report as well as an affective physiological synchrony measurement. First, we recorded the emotional autobiographical stories told by participants (“targets”, N = 28). Then, the targets watched their own videos as their heart rate (HR) was measured, and they reported on both a continuous and a discrete emotion scale what they felt while relaying the story. Next, we collected HR data from new participants (“observers”, N = 72) as they similarly rated the targets' valence and discrete emotional states. In order to test the contribution of sensorimotor cues and contextual cues to empathic accuracy, observers viewed some videos with audio, others without audio, and listened to a third set of only the audio. We hypothesized that empathic accuracy—a cognitive measure that is a proxy for mentalizing and is operationalized by the correlation between a target's reported emotions and an observer's inference of those emotions—would be greater when linguistic information is present. We also hypothesized that physiological synchrony, a proxy for experience sharing, would be greater in the video-only condition, which was limited to sensorimotor cues to infer the other's emotional state. Indeed, we found that empathic accuracy was greater when auditory information was present, and that HR synchrony was more prevalent when visual cues were presented alone. Having both information streams together did not enhance accuracy, yet it was the only condition in which both behavioral empathic-accuracy measures correlated with HR synchrony. This study provides evidence that separate experience sharing and mentalizing pathways are active in the same task.

N., Mairon, Nahum M., Stolk A., Knight R., and Perry A.Behavioral and EEG Measures Show no Amplifying Effects of Shared Attention on Attention or Memory..” Scientific Reports 10, no. 1 (2020): 1-11. Publisher's VersionAbstract

Shared attention experiments examine the potential differences in function or behavior when stimuli are experienced alone or in the presence of others, and when simultaneous attention of the participants to the same stimulus or set is involved. Previous work has found enhanced reactions to emotional stimuli in social situations, yet these changes might represent enhanced communicative or motivational purposes. This study examines whether viewing emotional stimuli in the presence of another person influences attention to or memory for the stimulus. Participants passively viewed emotionally-valenced stimuli while completing another task (counting flowers). Each participant performed this task both alone and in a shared attention condition (simultaneously with another person in the same room) while EEG signals were measured. Recognition of the emotional pictures was later measured. A significant shared attention behavioral effect was found in the attention task but not in the recognition task. Compared to event-related potential responses for neutral pictures, we found higher P3b response for task relevant stimuli (flowers), and higher Late Positive Potential (LPP) responses for emotional stimuli. However, no main effect was found for shared attention between presence conditions. To conclude, shared attention may therefore have a more limited effect on cognitive processes than previously suggested.

Y., Rum, and Perry A.Empathic Accuracy in Clinical Populations.” Frontiers in Psychiatry 11 (2020): 457. Publisher's VersionAbstract

Empathy, broadly defined as the ability to understand the other and to share others’ emotions, motivates prosocial behavior and underlies successful interpersonal relations. Dysfunctions in this ability may cause fundamental difficulties in social communication. Empathy has been measured in various ways, from self-report questionnaires to laboratory objective performance tests. Empathic accuracy (EA), i.e., the ability to accurately empathize, is measured using more complex and ecological paradigms, such as asking participants to infer filmed interactions, or having people narrate personal emotional stories then assessing the correspondence between the perceiver and the target of empathy as the criteria for empathic ability. This measure is particularly useful in the study of clinical populations, where deconstructing the multifaceted concept of empathy may contribute to a more complete understanding of specific clinical profiles. This paper presents a scoping review of the literature on EA in clinical populations, and on EA and clinical traits and states in nonclinical or high-risk populations. Following an exhaustive literature search, 34 studies were found eligible to be included in this review. The largest category was studies focused on EA in people with schizophrenia (31%; 11 papers), followed by studies focused on EA in autism spectrum disorders (ASD) and autistic traits in a nonclinical population (22%; 8 papers). Studies were also found on EA and depression tendencies, psychopathy, social anxiety, behavior disorders, and personality disorders, and a few other clinical conditions. The included studies varied on research aims, designs, sample sizes, and male:female ratios. The overall synthesized results suggest that EA is reduced in schizophrenia and ASD. In other clinical populations, the number of studies was very limited. We urge researchers to further examine EA in these less-studied populations. The review reveals a general underrepresentation of female participants in studies on EA in clinical populations. We suggest that future research address understudied clinical populations, such as those diagnosed with psychopathy. Subject, target, and situational variables should also be considered, with special attention to gender differences (and similarities), the association between EA abilities and adaptive functioning, and the study of individuals with clinical conditions as targets, not just observers, in EA tasks.

O., Rubinstein, Korem N., Perry A., and Shamay-Tsoory S.Different neural activations for an approaching friend versus stranger: Linking personal space to numerical cognition in developmental dyscalculia.” Brain & Behavior (2020): e01613. Publisher's VersionAbstract

Typically, humans place themselves at a preferred distance from others. This distance is known to characterize human spatial behavior. Here, we focused on neurocognitive conditions that may affect interpersonal distances. The current study investigated whether neurocognitive deficiencies in numerical and spatial knowledge may affect social perception and modulate personal space.

D., Cohen, Perry A., Mayseless N., and Shamay-Tsoory S.The role of oxytocin in implicit personal space regulation - an fMRI study.” Psychoneuroendocrinology 91 (2018): 206-215. Publisher's VersionAbstract

Personal space, defined as the distance individuals choose to maintain between themselves and others, is an indicator of affiliation and closeness. Most paradigms that measure personal space preferences involve explicit choice and therefore fail to examine the implicit aspects of such preferences. In the current study, we sought to investigate an implicit form of interpersonal space that is more closely related to real-life situations involving affiliation. We studied the effects of oxytocin (OT) on neural networks that involve affiliation and tested the impact on personal space preferences. In a double-blind placebo-controlled study, we asked participants to choose between two rooms that differed only in the distances between two stimuli. The stimuli were either social stimuli (two chairs) or non-social stimuli (table and plant). The behavioral results showed that OT caused participants to choose a closer space in social blocks but did not affect their choices in non-social blocks. Imaging results revealed an interaction between stimulus and treatment (OT/PL) in the dorsal striatum, an area that is related to approach motivation and is part of the reward circuitry. Specifically, OT increased activity in the dorsal striatum in the social blocks and decreased this activity in the non-social blocks. The results of the study strengthen the social salience theory regarding OT, indicating that OT does not uniformly affect all social responses and that context has a determining impact on our behavior.

A., Perry, Stiso J., Chang E.F., Lin J.J., Parvizi J., and Knight R.T.Mirroring in the Human Brain: Deciphering the Spatial-Temporal Patterns of the Human Mirror Neuron System, an ECoG study.” Cerebral Cortex 28, no. 3 (2018): 1039-1048. Publisher's VersionAbstract

2017 FEB 27 (NewsRx) – By a News Reporter-Staff News Editor at Pain Central Nervous System Week – Data detailed on Neurology - Cerebral Cortex Research have been presented. According [...]

N., Ensenberg, Perry A., and Aviezer H.Are you looking at me? Mu suppression modulation by facial expression direction.” Cognitive Affective & Behavioral Neuroscience 17, no. 1 (2017): 174 - 184. Publisher's VersionAbstract

Although we encounter numerous expressive faces on a daily basis, those that are not aimed at us will often be disregarded. Facial expressions aimed at our direction appear far more relevant and evoke an engaging affective experience, while the exact same expressions aimed away from us may not. While the importance of expression directionality is intuitive and commonplace, the neural mechanisms underlying this phenomenon are largely unknown. In the current study we measured EEG mu rhythm suppression, an established measure of mirror neuron activity, while participants viewed short video clips of dynamic facial expressions. Critically, the videos portrayed facial emotions which turned towards or away from the viewer, thus manipulating their degree of social relevance. Mirroring activity increased as a function of social relevance such that expressions turning toward the viewer resulted in increased sensorimotor activation (i.e., stronger mu suppression) compared to identical expression

A., Perry, Saunders S.N., Stiso J., Dewar C., Lubell J., Meling T.R., Solbakk A., Endestad T., and Knight R.T.Effects of prefrontal cortex damage on emotion understanding: EEG and behavioural evidence.” Brain: A Journal of Neurology 140, no. 4 (2017): 1086 - 1099. Publisher's VersionAbstract

Humans are highly social beings that interact with each other on a daily basis. In these complex interactions, we get along by being able to identify others' actions and infer their intentions, thoughts and feelings. One of the major theories accounting for this critical ability assumes that the understanding of social signals is based on a primordial tendency to simulate observed actions by activating a mirror neuron system. If mirror neuron regions are important for action and emotion recognition, damage to regions in this network should lead to deficits in these domains. In the current behavioural and EEG study, we focused on the lateral prefrontal cortex including dorsal and ventral prefrontal cortex and utilized a series of task paradigms, each measuring a different aspect of recognizing others' actions or emotions from body cues. We examined 17 patients with lesions including (n = 8) or not including (n = 9) the inferior frontal gyrus, a core mirror neuron system region, and com

D., Cohen, Perry A., Gilam G., Mayseless N., Gonen T., Hendler T., and Shamay-Tsoory S.G.The role of oxytocin in modulating interpersonal space: A pharmacological fMRI study.” Psychoneuroendocrinology 76 (2017): 77-83. Publisher's VersionAbstract

* We show that intranasal oxytocin (OT) increases personal distance from strangers. * OT reverses the activity of the left dorsomedial prefrontal cortex (dmPFC). * Under OT we observed higher activation in the dmPFC when a friend is approaching. * The effect of OT on personal space depends on the protagonist.

A., Perry, and Ben-Ami Bartal I.The Neurobiology of Empathy.” In Countertransference in Perspective, The double-edged sword of the patient-therapist emotional relationship, 2016.
I., Ben-Ami Bartal, and Perry A.The Evolution of Pro-social Behavior.” In Countertransference in Perspective, The double-edged sword of the patient-therapist emotional relationship, 2016.
A., Perry, Nichiporuk N., and Knight R.T.Where does one stand: a biological account of preferred interpersonal distance.” Social Cognitive & Affective Neuroscience 11, no. 2 (2016): 317 - 326. Publisher's VersionAbstract

What determines how close you choose to stand to someone? Why do some people prefer farther distances than others? We hypothesized that an important factor is one's sensory sensitivity level, i.e. how sensitive one is to nearby visual stimulation, noise, touch or smell. This study characterizes the behavioral, hormonal and electrophysiological metrics of interpersonal distance (IPD) preferences in relation to levels of sensory sensitivity. Using both an ecologically realistic task and electroencephalogram (EEG), we found that sensory sensitivity levels predicted IPD preferences, such that the more sensitive one is the farther distance they prefer. Furthermore, electrophysiological evidence revealed that individuals with higher sensory sensitivity show more alpha suppression for approaching stimuli, strengthening the notion that early sensory cortical excitability is involved in one's social decision of how close to stand to another. The results provide evidence that a core human metri

Z., Gao, Ye T., Shen M., and Perry A.Working memory capacity of biological movements predicts empathy traits.” Psychonomic Bulletin & Review 23, no. 2 (2016): 468 - 475. Publisher's VersionAbstract

Working memory (WM) and empathy are core issues in cognitive and social science, respectively. However, no study so far has explored the relationship between these two constructs. Considering that empathy takes place based on the others' observed experiences, which requires extracting the observed dynamic scene into WM and forming a coherent representation, we hypothesized that a sub-type of WM capacity, i.e., WM for biological movements (BM), should predict one's empathy level. Therefore, WM capacity was measured for three distinct types of stimuli in a change detection task: BM of human beings (BM; Experiment 1), movements of rectangles (Experiment 2), and static colors (Experiment 3). The first two stimuli were dynamic and shared one WM buffer which differed from the WM buffer for colors; yet only the BM conveyed social information. We found that BM-WM capacity was positively correlated with both cognitive and emotional empathy, with no such correlations for WM capacity of movement

L., Peled-Avron, Perry A., and Shamay-Tsoory S.G.The effect of oxytocin on the anthropomorphism of touch.” Psychoneuroendocrinology 66 (2016): 159-165. Publisher's VersionAbstract

* Oxytocin can enhance anthropomorphism of non-human objects. * Intranasal delivery of oxytocin increases the anthropomorphism of touch between two inanimate objects. * Touch plays a key role in the anthropomorphic effect of oxytocin.

A., Perry, Lwi S., Verstaen A., Dewar C., Levenson R.W., and Knight R.T.The role of the orbitofrontal cortex in regulation of interpersonal space: evidence from frontal lesion and frontotemporal dementia patients.” Social Cognitive & Affective Neuroscience 11, no. 12 (2016): 1894 - 1901. Publisher's VersionAbstract

Interpersonal distance is central to communication and complex social behaviors but the neural correlates of interpersonal distance preferences are not defined. Previous studies suggest that damage to the orbitofrontal cortex (OFC) is associated with impaired interpersonal behavior. To examine whether the OFC is critical for maintaining appropriate interpersonal distance, we tested two groups of patients with OFC damage: Patients with OFC lesions and patients with behavioral variant frontotemporal dementia. These two groups were compared to healthy controls and to patients with lesions restricted to the dorsolateral prefrontal cortex. Only patients with OFC damage showed abnormal interpersonal distance preferences, which were significantly different from both controls and patients with dorsolateral prefrontal damage. The comfortable distances these patients chose with strangers were significantly closer than the other groups and resembled distances normally used with close others. The

D., Gotthilf-Nezri, Lev M., Yehezkel O., Gilaie-Dotan S., Perry A., Bentin S., Bonneh Y., and Polat U.Training-induced recovery of undeveloped visual functions may be followed by improved perceptual functions: indication from adult with perceptual impairments.” Developmental Science 18, no. 1 (2015): 50-64. Publisher's VersionAbstract

Long-term deprivation of normal visual inputs can cause perceptual impairments at various levels of visual function, from basic visual acuity deficits, through mid-level deficits such as contour integration and motion coherence, to high-level face and object agnosia. Yet it is unclear whether training during adulthood, at a post-developmental stage of the adult visual system, can overcome such developmental impairments. Here, we visually trained LG, a developmental object and face agnosic individual. Prior to training, at the age of 20, LG's basic and mid-level visual functions such as visual acuity, crowding effects, and contour integration were underdeveloped relative to normal adult vision, corresponding to or poorer than those of 5–6 year olds (Gilaie-Dotan, Perry, Bonneh, Malach & Bentin, 2009). Intensive visual training, based on lateral interactions, was applied for a period of 9 months. LG's directly trained but also untrained visual functions such as visual acuity, crowding, binocular stereopsis and also mid-level contour integration improved significantly and reached near-age-level performance, with long-term (over 4 years) persistence. Moreover, mid-level functions that were tested post-training were found to be normal in LG. Some possible subtle improvement was observed in LG's higher-order visual functions such as object recognition and part integration, while LG's face perception skills have not improved thus far. These results suggest that corrective training at a post-developmental stage, even in the adult visual system, can prove effective, and its enduring effects are the basis for a revival of a developmental cascade that can lead to reduced perceptual impairments.

A., Perry, Levy-Gigi E., Richter-Levin G., and Shamay-Tsoory S.G.Interpersonal distance and social anxiety in autistic spectrum disorders: A behavioral and ERP study.” Social Neuroscience 10, no. 4 (2015): 354-365. Publisher's VersionAbstract

An inherent feature of social interactions is the use of social space or interpersonal distance-the space between one individual and another. Because social deficits are core symptoms of Autistic Spectrum Disorder (ASD), we hypothesized that individuals on this spectrum will exhibit abnormal interpersonal distance preferences. The literature on interpersonal distance in ASD is not conclusive. While some studies show preferences for closer distances among this group, others show preferences for farther distances than controls. A common symptom of ASD that may explain the variance in responses to interpersonal distance in this population is social anxiety (SA), which has been shown to correlate with interpersonal distance preferences. In the current study, we investigated interpersonal distance preferences in a group of individuals with ASD using both behavioral and ERP measures. We found greater variance in interpersonal distance preferences in the ASD group than in the control group. Furthermore, we showed that this variance can be explained by differences in SA level and can be predicted by the N1 amplitude, an early ERP component related to attention and discrimination processes. These results hint at the early sensory and attentional processes that may be affecting higher social behaviors, both in subclinical and in clinical populations.

A., Perry, Mankuta D., and Shamay-Tsoory S.G.Oxytocin promotes closer interpersonal distance among highly empathic individuals.” Social, Cognitive & Affective Neuroscience 10, no. 1 (2015): 3 - 9. Publisher's VersionAbstract

The space between people, or 'interpersonal distance', creates and defines the dynamics of social interactions and is a salient cue signaling responsiveness and feeling comfortable. This distance is implicit yet clearly felt, especially if someone stands closer or farther away than expected. Increasing evidence suggests that Oxytocin (OT) serves as a social hormone in humans, and that one of its roles may be to alter the perceptual salience of social cues. Considering that empathic ability may shape the way individuals process social stimuli, we predicted that OT will differentially affect preferred interpersonal distance depending on individual differences in empathy. Participants took part in two interpersonal distance experiments: In the first, they had to stop a (computer visualized) protagonist when feeling most comfortable; in the second, they were asked to choose the room in which they would later discuss intimate topics with another. Both experiments revealed an interaction be

S., Frenkel-Toledo, Bentin S., Perry A., Liebermann D.G., and Soroker N.Mirror-neuron system recruitment by action observation: Effects of focal brain damage on mu suppression.” NeuroImage 87 (2014): 127 - 137. Publisher's VersionAbstract

Mu suppression is the attenuation of EEG power in the alpha frequency range (8-12Hz), recorded over the sensorimotor cortex during execution and observation of motor actions. Based on this dual characteristic mu suppression is thought to signalize activation of a human analogue of the mirror neuron system (MNS) found in macaque monkeys. However, much uncertainty remains concerning its specificity and full significance. To further explore the hypothesized relationship between mu suppression and MNS activation, we investigated how it is affected by damage to cortical regions, including areas where the MNS is thought to reside. EEG was recorded in 33 first-event stroke patients during observation of video clips showing reaching and grasping hand movements. We examined the modulation of EEG oscillations at central and occipital sites, and analyzed separately the lower (8-10Hz) and higher (10-12Hz) segments of the alpha/mu range. Suppression was determined relative to observation of a non-

S., Frenkel-Toledo, Bentin S., Perry A., Liebermann D.G., and Soroker N.Dynamics of the EEG power in the frequency and spatial domains during observation and execution of manual movements.” Brain Research 1509 (2013): 43 - 57. Publisher's VersionAbstract

Mu suppression is the attenuation of EEG power in the alpha frequency range (8-12Hz) while executing or observing a motor action. Whereas typically observed at central scalp sites, there are diverging reports about the extent of the attenuation over the cortical mantle, its exact frequency range and the specificity of this phenomenon. We investigated the modulation of EEG oscillations in frequency-bands between 4 to 12Hz at frontal, central, parietal and occipital sites during the execution of manual movements and during observation of similar actions from allocentric (i.e., facing the actor) and egocentric (i.e., seeing the actor from behind) viewpoints. Suppression was determined relative to observation of a non-biological movement. Action observation elicited greater suppression in the lower (8-10Hz) compared to the higher mu range (10-12Hz), and greater suppression in the entire range (4-12Hz) at frontal and central sites compared to parietal and occipital sites. In addition, supp