@article { ISI:000279106500014,
	title = {DNA computing circuits using libraries of DNAzyme subunits},
	journal = {NATURE NANOTECHNOLOGY},
	volume = {5},
	year = {2010},
	month = {JUN},
	pages = {417-422},
	abstract = {Biological systems that are capable of performing computational operations(1-3) could be of use in bioengineering and nanomedicine(4,5), and DNA and other biomolecules have already been used as active components in biocomputational circuits(6-13). There have also been demonstrations of DNA/RNA-enzyme-based automatons(12), logic control of gene expression(14), and RNA systems for processing of intracellular information(15,16). However, for biocomputational circuits to be useful for applications it will be necessary to develop a library of computing elements, to demonstrate the modular coupling of these elements, and to demonstrate that this approach is scalable. Here, we report the construction of a DNA-based computational platform that uses a library of catalytic nucleic acids (DNAzymes)(10), and their substrates, for the input-guided dynamic assembly of a universal set of logic gates and a half-adder/half-subtractor system. We demonstrate multilayered gate cascades, fan-out gates and parallel logic gate operations. In response to input markers, the system can regulate the controlled expression of anti-sense molecules, or aptamers, that act as inhibitors for enzymes.},
	issn = {1748-3387},
	doi = {10.1038/NNANO.2010.88},
	author = {Elbaz, Johann and Lioubashevski, Oleg and Wang, Fuan and Remacle, Francoise and Levine, Raphael D. and Willner, Itamar}
}
