@article {10160,
	title = {Mechanical behavior of osteoporotic bone at sub-lamellar length scales},
	journal = {FRONTIERS IN MATERIALS},
	volume = {13},
	year = {2015},
	pages = {1-7},
	abstract = {Osteoporosis is a disease known to promote bone fragility but the effect on the mechanicalproperties of bone material, which is independent of geometric effects, is particularlyunclear. To address this problem, micro-beams of osteoporotic bone were prepared usingfocused ion beam microscopy and mechanically tested in compression using an atomicforce microscope while observing them using in situ electron microscopy.This experimentalapproach was shown to be effective for measuring the subtle changes in the mechanicalproperties of bone material required to evaluate the effects of osteoporosis. Osteoporoticbone material was found to have lower elastic modulus and increased strain to failurewhen compared to healthy bone material, while the strength of osteoporotic and healthybone was similar. Surprisingly, the increased strain to failure for osteoporotic bone materialprovided enhanced toughness relative to the control samples, suggesting that lowering ofbone fragility due to osteoporosis is not defined by material performance. A mechanism issuggested based on these results and previous literature that indicates degradation of theorganic material in osteoporosis bone is responsible for resultant mechanical properties.},
	author = {Jimenez-Palomar, Ines and Shipov, Anna and Ron Shahar and Barber, Asa H.}
}
