@article {10231,
	title = {Importance of the integrity of trabecular bone to the relationship between load and deformation of rat femora- an optical metrology study},
	journal = {JOURNAL OF MATERIALS CHEMISTRY},
	volume = {18},
	number = {32},
	year = {2008},
	pages = {3855-3864},
	abstract = {Bone\&nbsp;is a composite hierarchical structure composed\&nbsp;of\&nbsp;a cortical shell and inner\&nbsp;trabecular\&nbsp;tissue. One\&nbsp;ofthe\&nbsp;most basic questions in whole-bone\&nbsp;function is\&nbsp;the\&nbsp;relative contributions\&nbsp;of\&nbsp;cortical and\&nbsp;trabecular\&nbsp;bonetissues\&nbsp;to\&nbsp;the\&nbsp;loaded whole\&nbsp;bone. In this\&nbsp;study,\&nbsp;the\&nbsp;manner in which\&nbsp;the\&nbsp;cortical surfaces\&nbsp;of\&nbsp;an\&nbsp;intact proximal\&nbsp;rat\&nbsp;femur deform under\&nbsp;load\&nbsp;is compared\&nbsp;to\&nbsp;the\&nbsp;same femur after some\&nbsp;of\&nbsp;the\&nbsp;trabecular\&nbsp;bone\&nbsp;inthe\&nbsp;distal femoral neck was removed.\&nbsp;The\&nbsp;surface displacements were measured by electronic speckle pattern interferometry (ESPI) and\&nbsp;the\&nbsp;extent\&nbsp;of\&nbsp;trabecular\&nbsp;bone\&nbsp;removed was determined by high resolution micro-CT scanning.\&nbsp;The\&nbsp;results show that after damaging\&nbsp;the\&nbsp;trabecular\&nbsp;bone\&nbsp;tissue in\&nbsp;the\&nbsp;distal femoral neck,\&nbsp;the\&nbsp;manner in which compressive loads are transformed\&nbsp;to\&nbsp;other regions\&nbsp;of\&nbsp;the\&nbsp;femoral neck changed.The\&nbsp;whole\&nbsp;bone\&nbsp;behaved in a {\textquoteright}stiffer{\textquoteright} manner. This demonstrates\&nbsp;the\&nbsp;importance\&nbsp;of\&nbsp;connectivity\&nbsp;of\&nbsp;thetrabeculae and that beyond a certain threshold\&nbsp;of\&nbsp;damage\&nbsp;the\&nbsp;normal\&nbsp;load-transferring mechanism is impaired. Since these experiments were carried out in a non-contact non-destructive manner in a wet environment and\&nbsp;the\&nbsp;rat\&nbsp;femur was loaded in a close-to\&nbsp;physiological manner, we postulate that our results have a direct relevance\&nbsp;to\&nbsp;the\&nbsp;in vivo biomechanical behavior\&nbsp;of\&nbsp;the\&nbsp;femoral neck.},
	url = {http://pubs.rsc.org/en/Content/ArticleLanding/2008/JM/b805661g$\#$!divAbstract},
	author = {Barak, Meir Max and Weiner, Steve and Ron Shahar}
}
