Publications

2014
Ryu RJ, Eyal S, Kaplan HG, Akbarzadeh A, Hays K, Puhl K, Easterling TR, Berg SL, Scorsone KA, Feldman EM, et al. Pharmacokinetics of doxorubicin in pregnant women. Cancer Chemother Pharmacol. 2014;73 :789-97.
Deo AK, Borson S, Link JM, Domino K, Eary JF, Ke B, Richards TL, Mankoff DA, Minoshima S, O'Sullivan F, et al. Activity of P-Glycoprotein, a β-Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease. J Nucl Med. 2014;55 :1106-11.
Qawasmi I, Shmuel M, Eyal S. Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging. Front Pharmacol. 2014;5 :257.
2013
Stiebel-Kalish H, Eyal S, Steiner I. The role of aquaporin-1 in idiopathic and drug-induced intracranial hypertension. Med Hypotheses. 2013;81 :1059-62.
2012
Rubinchik-Stern M, Eyal S. Drug Interactions at the Human Placenta: What is the Evidence?. Front Pharmacol. 2012;3 :126.
Portnoy E, Gurina M, Magdassi S, Eyal S. Evaluation of the near infrared compound indocyanine green as a probe substrate of P-glycoprotein. Mol Pharm . 2012;9 :3595-601.
2010
Eyal S, Kim JD, Anderson GD, Buchanan ML, Brateng DA, Carr D, Woodrum DE, Easterling TR, Hebert MF. Atenolol pharmacokinetics and excretion in breast milk during the first 6 months postpartum. J Clinical Pharmacol . 2010;50 :1301-9. .
Claessens AJ, Risler LJ, Eyal S, Shen DD, Easterling TR, Hebert MF. CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos . 2010;38 :1393-6.
Eyal S, Easterling TR, Carr D, Umans JG, Miodovnik M, Hankins JDV, Clark SM, Risler L, Wang J, Kelly EJ, et al. Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos . 2010;38 :833-40.
Eyal S, Ke B, Muzi M, Link JM, Mankoff DA, Collier A, Unadkat JD. Regional P-glycoprotein activity and inhibition at the human blood-brain barrier as imaged by positron emission tomography. Clin Pharmacol Ther . 2010;87 :579-85. .
2009
Eyal S, Hsiao P, Unadkat JD. Drug interactions at the blood-brain barrier: fact or fantasy?. Pharmacol Ther . 2009;123 :80-104.
Eyal S, Chung F, Muzi M, Link JM, Mankoff DA, Kaddoumi A, O’Sullivan F, Hebert MF, Unadkat JD. Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant non-human primate. J Nucl Med . 2009;50 :798-806.
Swed A, Eyal S, Madar I, Kontante H, Weiss L, Hoffman A. The role of P-glycoprotein in intestinal transport versus the BBB transport of tetraphenylphosphonium (TPP). Mol Pharm . 2009;6 :1883-90.
Chung F, Eyal S, Muzi M, Link JM, Mankoff DA, Kaddoumi A, Hsiao P, O’Sullivan F, Unadkat JD. Tissue P-glycoprotein activity in the pregnant nonhuman primate changes with gestational age. Br J Pharmacol . 2009;159 :394-404.
2008
Unadkat JD, Chung F, Sasongko L, Whittington D, Eyal S, Mankoff DA, Collier AC, Muzi M, Link J. Rapid solid-phase extraction method to quantify [11C]-verapamil, and its [11C]-metabolites, in human and macaque plasma. Nucl Med Biol. 2008;35 :911-7.
2007
Shimshoni JA, Dalton EC, Jenkins A, Eyal S, Ewan K, Williams RS, Pessah N, B Y, Harwood AJ, Bialer M. The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior. Mol Pharmacol . 2007;71 :884-92.
2006
Eyal S, Lamb JG, Smith-Yockman M, Yagen B, Fibach E, Altschuler Y, White HS, Bialer M. The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver. Br J Pharmacol . 2006;149 :250-60.
2005
Eyal S, Yagen B, Shimshoni J, Bialer M. Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives. Biochem Pharmacol. 2005;69 :1501-8.
2004
Hoffman A, Stepensky D, Lavi E, Eyal S, Klausner E, Friedman M. Pharmacokinetic and pharmacodynamic aspects of gastroretentive dosage forms. Int J Pharm . 2004;277 :141-153.
Eyal S, Yagen B, Sobol E, Altschuler Y, Bialer M. The activity of antiepileptic drugs as histone deacetylase inhibitors. Epilepsia. 2004;45 :737-44.

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