We study molecular recognition of taste and smell compounds using atomistic computational methods, as well as psycophysics techniques and cell-based methods. In particular, we study molecular recognition and signal transduction of bitter  and sweet taste receptors and other GPCRs. We established the BitterDB database of bitter compounds http://bitterdb.agri.huji.ac.il and have demonstrated effects of bitter taste on emotions (Dubovski et al, 2017 authors.elsevier.com/a/1U~fR3O579O9gL). Ongoing work includes genetic differences involved in taste perception, structure-taste activity and discovery of novel taste receptor ligands and taste modifiers.