Publications

Oxytocin is a peptide hormone with high affinity to both Zn²⁺ and Cu²⁺ ions compared to other metal ions. This affinity makes oxytocin an attractive recognition layer for monitoring the levels of these essential ions in biofluids. Native oxytocin cannot differentiate between Cu²⁺ and Zn²⁺ ions and hence it is not useful for sensing Zn²⁺ in the presence of Cu²⁺. We elucidated the effect of the terminal amine group of oxytocin on the affinity toward Cu²⁺ using theoretical calculations. We designed a new Zn²⁺ selective oxytocin-based biosensor that utilizes the terminal amine for surface anchoring, also preventing the response to Cu²⁺. The biosensor shows exceptional selectivity and very high sensitivity to Zn²⁺ in impedimetric biosensing. This study shows for the first time an oxytocin derived sensor that can be used directly for sensing Zn²⁺ in the presence of Cu²⁺.

Organoborons are extremely important for synthetic organic chemistry; they can serve as advanced intermediates for a variety of transformations. Such a well-known transformation involves the loss of the boron moiety, creating alkyl radicals. Although these originally developed protocols for alkyl radical generation remain in active use today, in recent years their α-boryl carbon-centred radicles have been joined by a new array of radical generation strategies that offer a unique reactivity to forge a wider diversity of organoborones that often operate under mild and benign conditions. Herein, we will highlight the stability and reactivity of α-borylalkyl radicals and their remarkably recent advances in order to further utilise them for C–C and C–heteroatom bond formation. Their use for this purpose has been reported over the last decade in an attempt to guide the synthetic community. Various transition-metal and metal-free methods for their generation are presented, and more advanced photoredox approaches are discussed, mainly for the period of time 2009-2019.

העולם המערבי תוהה לפשר תשוקת המוות הדוחפת לעבר הטרור, ההרג וההתאבדות. מסה זו עוסקת בתשוקה דומה, מתמיהה לא פחות, זו העומדת ביסוד ההגות של המאה ה-20. בעקבות הרצאותיו של אלכסנדר קוז'ב בפריז, בעומק כתיבתם של ז'ורז' בטאיי, מוריס בלאנשו, ז'אק דרידה וז'אק לאקאן רוחשת ליריקה של הרס, כמיהה לתהום המגיחה מבעד למעטה החשיבה הביקורתית.

This paper examines the effect of party affiliation on an individual’s political views.  To do this, we exploit the party realignment that occurred in the U.S. due to abortion becoming a more prominent and highly partisan issue over time.  We show that abortion was not a highly partisan issue in 1982, but a person’s abortion views in 1982 led many to switch parties over time as the two main parties diverged in their stances on this issue.  We find that voting for a given political party in 1996, due to the individual’s initial views on abortion in 1982, has a substantial effect on a person’s political, social, and economic attitudes in 1997.  These findings are stronger for highly partisan political issues, and are robust to controlling for a host of personal views and characteristics in 1982 and 1997.  As individuals realigned their party affiliation in accordance with their initial abortion views, their other political views followed suit.

This work presents the fabrication of 3D-printed composite objects based on copper(II) 1D coordination polymer (CP1) decorated with thymine along its chains with potential utility as an environmental humidity sensor and as a water sensor in organic solvents. This new composite object has a remarkable sensitivity, ranging from 0.3% to 4% of water in organic solvents. The sensing capacity is related to the structural transformation due to the loss of water mols. that CP1 undergoes with temperature or by solvent mols.′ competition, which induces significant change in color simultaneously. The CP1 and 3D printed materials are stable in air over 1 yr and also at biol. pHs (5-7), therefore suggesting potential applications as robust colorimetric sensors. These results open the door to generate a family of new 3D printed materials based on the integration of multifunctional coordination polymers with organic polymers.

SummaryThis article focuses on a chapter in a manual on circumcision written in Worms in the thirteenth century by Jacob and Gershom haGozrim (the circumcisers). The third chapter of the manual contains medical instruction on how to attend to women in labour and other gynaecological conditions. Whereas the first two chapters of the manual were published in the late nineteenth century, the midwifery chapter has only been recently examined. This article is comprised of a translation of the midwifery text(s) along with an introduction to the text and the community practices it reflects. It outlines the cooperation between medical practitioners, male and female, Jewish and Christian, and discusses the medical remedies recommended and some practices current in thirteenth-century Germany.