Clinical and laboratory observations: Naproxen as an alternative to aspirin for the treatment of arthritis of rheumatic fever: a randomized trial.

Citation:

Hashkes PJ, Tauber T, Somekh E, Brik R, Barash J, Mukamel M, Harel L, Lorber A, Berkovitch M, Uziel Y. Clinical and laboratory observations: Naproxen as an alternative to aspirin for the treatment of arthritis of rheumatic fever: a randomized trial. The Journal of Pediatrics [Internet]. 2003;143 :399 - 401.

Abstract:

We performed a prospective, randomized, open-label equivalence study comparing the use of naproxen to aspirin in 33 patients with rheumatic fever. The mean time until resolution of arthritis was 2.9±2.9 days in both groups. Liver enzyme elevations were more frequent in the aspirin group (P=.002). We conclude that naproxen is as effective, is easier to use, and is safer than aspirin in the treatment of the arthritis of rheumatic fever.

Website