A Novel Approach That May Explain the Role of Staphylococcus aureus, Polycations, Neutrophils Pro-Inflammatory Agonists and the Bacteriolysis and Auto Immune Phenomena as Possible Major Events in the Pathogenesis of Atopic Dermatitis: A Working Hypothesis

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A Novel Approach That May Explain the Role of Staphylococcus aureus, Polycations, Neutrophils Pro-Inflammatory Agonists and the Bacteriolysis and Auto Immune Phenomena as Possible Major Events in the Pathogenesis of Atopic Dermatitis: A Working Hypothesis

Abstract:

 

The aim of the present short communication is to shed a novel light on the auto immune disorder atopic dermatitis by discussing the possible role played by the plethora of toxic agents released by  Staphylococcus aureus which can act in a tight synergism with neutrophils derived cationic polyelectrolytes  as related to the pathogenesis of atopic dermatitis (AD) [1,2]. This disorder results in  inflammation of the  skin characterized by itchiness,  red  skin,  a  rash,  by   the  accumulations  of  large numbers of Staphylococcus  aureus  their toxins [2] and pro- inflammatory agents secreted by migrating neutrophiles [3], are considered the main cause of AD pathogenicity.

 

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Last updated on 11/01/2019