Sulfation pattern dependent Iron (III) mediated interleukin-8 glycan binding

Citation:

Francesco Brunori, Deepak Kumar Padhi, Israel Alshanski, Joanna Freyse, Jan-Niklas Dürig, Anja Penk, Luigi Vaccaro, Mattan Hurevich, Jörg Rademann, and Shlomo Yitzchaik. 2021. “Sulfation pattern dependent Iron (III) mediated interleukin-8 glycan binding.” ChemBioChem, 22, Pp. 1-22. Publisher's Version
Sulfation pattern dependent Iron (III) mediated interleukin-8 glycan binding

Abstract:

Cytokines such as interleukin-8 activate the immune system during infection and interact with sulfated glycosaminoglycans with specific sulfation patterns. In some cases, these interactions are mediated by metal ion binding which can be used to tune surface-based glycan-protein interactions. We evaluated the effect of both hyaluronan sulfation pattern and Fe3+ on interleukin-8 binding by electrochemical impedance spectroscopy and surface characterizations. Our results show that sulfation pattern and metal ion interactions have a synergistic effect in tuning the electrochemical response of the glycated surfaces to the cytokine.

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Last updated on 12/15/2021