Citation:
D N Shapiro, Varani J, Ginsburg I. Activation of a murine T-cell hybridoma by cationized bacteria. Immunology. 1989;67 (4) :478-483.
Abstract:
Cationic particles interact by electrostatic forces with membrane components of diverse cell types, including lymphocytes. Contact with cationized streptococci was shown to induce a murine T-cell hybridoma to transcribe lymphokine mRNA as well as secrete interleukin-2. This activation was accompanied by a rise in intracellular calcium. Cationized streptococci-induced activation of this T-cell hybridoma could be specifically inhibited by either chelating extracellular calcium or by treating with CD4 monoclonal antibody. These data indicate that the in vitro behaviour of T cells can be modulated by charged microbial particles; such interactions may have relevance for chronic inflammation associated with some bacterial infections.Publication Global ID: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1385317/