Abstract:

It is alarming that today clinicians are still helpless trying to cope with life-threatening sequelae of severe microbial infections, which very often terminates in sepsis, septic shock and death. According to CDC (The Centers for Disease Control and Prevention) today the annual incidence of sepsis in the USA affects as many as 7,50,000 hospitalized patients and mortality rates are about 40% [1]. As of today, all the clinical trials of sepsis, which had tried the efficacy of only a single antagonist at a time, had failed to protect against septic shock, a disorder obviously caused by multi-factorial processes. Even the “hope of sepsis“, activated protein C (APC), has recently been discontinued. Today, no effective treatment for sepsis is available and the morality rates are climbing steadily also because of the rapid acquisition of antibiotic resistance.

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