Citation:
Yarom R, Sherman Y, More R, Ginsburg I, Borinski R, Yagen B. T-2 toxin effect on bacterial infection and leukocyte functions. Toxicology and Applied Pharmacology. 1984;75 (1) :60-68.
![T-2 toxin effect on bacterial infection and leukocyte functions T-2 toxin effect on bacterial infection and leukocyte functions](https://scholars.huji.ac.il/sites/default/files/styles/book_cover/public/isaacginsburg/files/toxicology_and_applied_pharmacology_1984.gif?m=1424685855&itok=tLMYgrYd)
Abstract:
The effects of T-2 toxin on bacterial infection and leukocyte function and structure were examined in vivo and in vitro. Rats were innoculated with staphylococci after pretreatment with or without T-2 toxin. The T-2 pretreated rats failed to mount a cellular response to the bacteria. Blood and bone marrow cells were markedly suppressed by the T-2 toxin, the myeloid series being the most affected. In vitro studies with human leukocytes showed that small, nonkilling doses of T-2 toxin inhibited chemotaxis, chemiluminescence stimulated by bacteria, and phagocytosis of bacteria. It was concluded that this inhibition may contribute towards sepsis and rapid onset of death in T-2 toxin poisoning.Publication Global ID: http://www.ncbi.nlm.nih.gov/pubmed/6464023