The Breaking Beads Approach for Photocleavage from Solid Support

Citation:

Yasmeen Bakhatan, Israel Alshanski, Dana Grunhaus, and Mattan Hurevich. 2020. “The Breaking Beads Approach for Photocleavage from Solid Support.” Organic & Biomolecular Chemistry.
The Breaking Beads Approach for Photocleavage from Solid Support

Abstract:

Photocleavage from polystyrene beads is a pivotal reaction for solid phase synthesis that relies on photolabile linkers. Photocleavage from intact porous polystyrene beads is not optimal because light cannot penetrate into the beads and the surface area exposed to irradiation is limited. Thus, hazardous, technically challenging and expensive setups are used for photocleavage from intact beads. We developed a new concept in which grinding the beads during or prior to irradiation is employed as an essential part of the photocleavage process. By grinding the beads we are exposing more surface area to the light source, hence, photocleavage can be performed even using a simple benchtop LED setup. This approach proved very efficient for photocleavage of various model compounds including fully protected oligosaccharides.

 

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Last updated on 09/17/2021