Lensless Micro-endoscopy

Micro-endoscopes use optical fibers to obtain microscopic images deep inside the body, while keeping the tissue damage as low as possible and requiring no electronics or cameras inside the body. The fibers, usually Multi-Core-Fibers (MCF), guide the light to and from the tissue and can be as small as a few hundreds of microns while obtaining images with a resolution of a few microns, making them suitable for imaging neurons and cells. However, these state-of-the-art devices are still far from perfect: They require bulky optical elements (e.g. lenses) at their ends; Obtain only 2d images of the tissue; And suffer from suboptimal resolution. Currently, solutions to these problems are either very slow or sensitive to bending of the fibers thus making them unfeasible for real-life applications.

An experimental setup, incorporating Multi-Core-Fiber for Super-Resolution imaging. Image Credit: Noam Shekel

We are working on the development of lensless bend-insensitive micro-endoscopes for real-time high-resolution 3D imaging, by exploiting the advanced Properties of the light guided through the MCF. The guided light is filled with spatial, temporal, spectral, and statistical information that we measure by advanced optical and computational techniques. We hope to improve a variety of methods for many applications: from clinical procedures, through biomedical investigations, all the way to in-vivo deep-tissue imaging.

mcf_sub_pixels

Previous group works:
Badt, Noam, and Ori Katz. “Label-free video-rate micro-endoscopy through flexible fibers via Fiber Bundle Distal Holography (FiDHo)”. arXiv preprint arXiv:2102.06482 (2021).
Shekel, Noam, and Ori Katz. “Using fiber-bending-generated speckles for improved working distance and background rejection in lensless micro-endoscopy”. Opt. Lett. 45.15 (2020): , 45, 15, 4288–4291
Weiss, Uri, and Ori Katz. “Two-photon lensless micro-endoscopy with in-situ wavefront correction”. Optics Express 26.22 (2018): , 26, 22, 28808–28817.
Porat, Amir, et al. “Widefield lensless imaging through a fiber bundle via speckle correlations”. Optics express 24.15 (2016): , 24, 15, 16835–16855.